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dc.contributor.otherProducción Científica UCH 2020-
dc.contributor.otherUCH. Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos-
dc.creatorPenadés Fons, Mariola-
dc.creatorViana Martín, David-
dc.creatorGarcía Quirós, Ana-
dc.creatorMuñoz Silvestre, Asunción-
dc.creatorMoreno Grúa, Elena-
dc.creatorPérez Fuentes, Sara-
dc.creatorPascual Amorós, Juan José-
dc.creatorCorpa Arenas, Juan Manuel-
dc.creatorSelva Martínez, Laura-
dc.date2020-
dc.date.accessioned2021-06-12T04:00:54Z-
dc.date.available2021-06-12T04:00:54Z-
dc.date.issued2020-02-13-
dc.identifier.citationPenadés, M., Viana, D., García-Quirós, A., Muñoz-Silvestre, A., Moreno-Grua, E., Pérez-Fuentes, S. et al. (2020). Differences in virulence between the two more prevalent Staphylococcus aureus clonal complexes in rabbitries (CC121 and CC96) using an experimental model of mammary gland infection. Veterinary Research, vol. 51, art. 11 (13 feb.). DOI: https://doi.org/10.1186/s13567-020-0740-1-
dc.identifier.issn0928-4249.-
dc.identifier.issn1297-9716 (Electrónico).-
dc.identifier.urihttp://hdl.handle.net/10637/12787-
dc.descriptionEste artículo se encuentra disponible en la siguiente URL: https://veterinaryresearch.biomedcentral.com/track/pdf/10.1186/s13567-020-0740-1.pdf-
dc.description.abstractStaphylococcal mastitis is a major health problem in humans and livestock that leads to economic loss running in millions. This process is currently one of the main reasons for culling adult rabbit does. Surprisingly, the two most prevalent S. aureus lineages isolated from non-differentiable natural clinical mastitis in rabbits (ST121 and ST96) generate different immune responses. This study aimed to genetically compare both types of strains to search for possible dissimilarities to explain differences in immune response, and to check whether they showed similar virulence in in vitro tests as in experimental intramammary in vivo infection. The main differences were observed in the enterotoxin gene cluster (egc) and the immune-evasion-cluster (IEC) genes. While isolate ST121 harboured all six egc cluster members (seg, sei, selm, seln, selo, selu), isolate ST96 lacked the egc cluster. Strain ST96 carried a phage integrase Sa3 (Sa3int), compatible with a phage integrated into the hlb gene (β-haemolysin-converting bacteriophages) with IEC type F, while isolate ST121 lacked IEC genes and the hlb gene was intact. Moreover, the in vitro tests confirmed a different virulence capacity between strains as ST121 showed greater cytotoxicity for erythrocytes, polymorphonuclear leukocytes and macrophages than strain ST96. Differences were also found 7 days after experimental intramammary infection with 100 colony-forming units. The animals inoculated with strain ST121 developed more severe gross and histological mastitis, higher counts of macrophages in tissue and of all the cell populations in peripheral blood, and a significantly larger total number of bacteria than those infected by strain ST96.-
dc.formatapplication/pdf-
dc.language.isoen-
dc.language.isoes-
dc.publisherSpringer Nature.-
dc.relationEste trabajo fue financiado por el Ministerio de Economía y Competitividad (MINECO) del Gobierno de España a través de la beca AGL2014-53405-C2-2-P, por la Universidad CEU Cardenal Herrera, por el Ministerio de Educación, Cultura y Deporte del Gobierno de España a través de las becas AP2010-3907 y FPU17/02708 y, finalmente, por la Generalitat Valenciana a través del proyecto ACIF/2016/085.-
dc.relationUCH. Financiación Nacional-
dc.relationUCH. Financiación Autonómica-
dc.relationUCH. Financiación Universidad-
dc.relation.ispartofVeterinary Research, vol. 51.-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.es-
dc.subjectBacteriología veterinaria.-
dc.subjectMastitis.-
dc.subjectGlándulas mamarias - Inflamación.-
dc.subjectMammary glands - Inflammation.-
dc.subjectEstafilococos.-
dc.subjectConejos - Enfermedades.-
dc.subjectStaphylococcus.-
dc.subjectRabbits - Diseases.-
dc.subjectVeterinary bacteriology.-
dc.titleDifferences in virulence between the two more prevalent "Staphylococcus aureus" clonal complexes in rabbitries (CC121 and CC96) using an experimental model of mammary gland infection-
dc.typeArtículo-
dc.identifier.doihttps://doi.org/10.1186/s13567-020-0740-1-
dc.relation.projectIDAGL2014-53405-C2-2-P-
dc.relation.projectIDAP2010-3907-
dc.relation.projectIDFPU17/02708-
dc.relation.projectIDACIF/2016/085-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos




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