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Título : Thioredoxin delays photoreceptor degeneration, oxidative and inflammation alterations in retinitis pigmentosa
Autor : Gimeno Hernández, Roberto.
Cantó Catalá, Antolín.
Fernández Carbonell, Ángel.
Olivar Rivas, Teresa.
Hernández Rabaza, Vicente.
Almansa Frías, María Inmaculada.
Miranda Sanz, María.
Materias: Crecimiento - Factores - Uso terapéutico.Growth factors - Therapeutic use.Glutatión - Uso terapéutico.Retina - Diseases - Treatment.Retinitis pigmentaria - Tratamiento.Estrés oxidativo - Tratamiento.Oxidative stress - Treatment.Glutathione - Therapeutic use.Tiorredoxina - Uso terapéutico.Thioredoxin - Therapeutic use.Retinitis pigmentosa - Treatment.Retina - Enfermedades - Tratamiento.
Fecha de publicación : 23-dic-2020
Editorial : Frontiers Media.
Citación : Gimeno-Hernández, R., Cantó, A., Fernández-Carbonell, A., Olivar, T., Hernández-Rabaza, V., Almansa, I. et al. (2020). Thioredoxin delays photoreceptor degeneration, oxidative and inflammation alterations in Retinitis Pigmentosa. Frontiers in Pharmacology, vol. 11, art. 590572 (23 dec.). DOI: https://doi.org/10.3389/fphar.2020.590572
Resumen : Retinitis pigmentosa (RP) is an inherited ocular disorder with no effective treatment. RP onset and progression trigger a cascade of retinal disorders that lead to the death of photoreceptors. After photoreceptors death, neuronal, glial and vascular remodeling can be observed in the retina. The purpose of this study was to study if thioredoxin (TRX) administration is able to decrease photoreceptor death in an animal model of RP (rd1 mouse), but also if it is able to modulate the retinal oxidative stress, glial and vascular changes that can be observed as the disease progresses. Wild type and rd1 mice received several doses of TRX. After treatment, animals were euthanized at postnatals days 11, 17, or 28. Glutathione (GSH) and other thiol compounds were determined by high performance liquid chromatography (HPLC). Glial fibrilary acidic protein (GFAP) and anti-ionized calcium binding adaptor molecule 1 (Iba1) were studied by immunohistochemistry. Vascular endothelial growth factor (VEGF) and hepatic growth factor (HGF) expression were determined by western blot. TRX administration significantly diminished cell death in rd1 mouse retinas and increased GSH retinal concentrations at postnatal day 11 (PN11). TRX was also able to reverse glial alterations at PN11 and PN17. No alterations were observed in retinal VEGF and HGF expression in rd1 mice. In conclusion, TRX treatment decreases photoreceptor death in the first stages of RP and this protective effect may be due in part to the GSH system activation and to a partially decrease in inflammation.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://www.frontiersin.org/articles/10.3389/fphar.2020.590572/full
URI : http://hdl.handle.net/10637/12677
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 1663-9812 (Electrónico).
Aparece en las colecciones: Dpto. Ciencias Biomédicas

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