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Título : Efficacy of platelet-rich plasma as an adjuvant to surgical carpal ligament release : a prospective, randomized controlled clinical trial
Autor : Trull Ahuir, Carmen.
Sala Cuartero, Diego.
Chismol Abad, Joaquín.
Vila Caballer, María Amparo.
Lisón Párraga, Juan Francisco.
Materias: Muñeca (Articulación) - Cirugía.Wrist - Surgery.Ligamentos - Heridas y lesiones - Tratamiento.Ligaments - Wounds and injuries - Treatment.Ligamentos - Cirugía.Blood platelets - Therapeutic use.Wrist - Wounds and injuries - Treatment.Ligaments - Surgery.Blood plasma - Therapeutic use.Plasma sanguíneo - Uso terapéutico.Plaquetas - Uso terapéutico.Muñeca (Articulación) - Heridas y lesiones - Tratamiento.
Fecha de publicación : 7-feb-2020
Editorial : Nature Research.
Citación : Trull-Ahuir, C., Sala, D., Chismol-Abad, J., Vila Caballer, M. & Lisón, J.F. (2020). Efficacy of platelet-rich plasma as an adjuvant to surgical carpal ligament release: a prospective, randomized controlled clinical trial. Scientific Reports, vol. 10, art. 2085 (07 feb.). DOI: https://doi.org/10.1038/s41598-020-59113-0
Resumen : The purpose of this study is to evaluate the efficiency of local platelet-rich plasma (PRP) injection as an adjuvant treatment after carpal ligament release. We conducted a prospective randomized, tripleblinded, controlled trial. Fifty participants with mild to extreme carpal tunnel syndrome (CTS) were randomly assigned either to the PRP (n = 25) or the platelet-poor plasma (PPP, n = 25) group. After performing open surgical release of the carpal ligament, the inside of the carpal tunnel was irrigated with 3 mL of PRP or PPP according to each participant’s group allocation. The primary outcome was hand grip strength (HGS). Secondary outcomes were the time taken off work after surgery (in days) and scores on the Wong–Baker Faces Scale, Boston Carpal Tunnel Questionnaire, and Southampton Wound Assessment Scale. We evaluated patients before treatment and at 6-weeks. As expected, the pain levels, symptom severity, and functional status improved in all the patients after surgery. However, intragroup analysis revealed that only the participants in the PRP group had regained their pre-operative HGS levels at 6-weeks follow-up. These findings indicate that PRP is an effective adjuvant treatment in patients with mild to severe CTS who require surgery.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://www.nature.com/articles/s41598-020-59113-0.pdf
URI : http://hdl.handle.net/10637/12649
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2045-2322 (Electrónico).
Aparece en las colecciones: Dpto. Medicina y Cirugía

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