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Título : The effect of a mindfulness-based therapy on different biomarkers among patients with inflammatory bowel disease : a randomised controlled trial
Autor : González Moret, Rafael.
Cebolla Martí, Ausiàs.
Cortés Rizo, Xavier.
Baños Rivera, Rosa María.
Navarrete Hidalgo, Jaime.
Rubia Ortí, José Enrique de la.
Lisón Párraga, Juan Francisco.
Soria López, José Miguel.
Materias: Intestinos - Inflamación - Tratamiento.Biochemical markers.Marcadores bioquímicos.Meditation in medicine.Intestines - Diseases - Treatment.Aparato digestivo - Enfermedades - Tratamiento.Digestive organs - Diseases - Treatment.Intestine - Inflammation - Treatment.Meditación - Aplicaciones en medicina.Intestinos - Enfermedades - Tratamiento.
Fecha de publicación : 8-abr-2020
Editorial : Nature Research.
Citación : González-Moret, R., Cebolla, A., Cortés, X., Baños, R.M., Navarrete, J., Rubia, J.E. et al. (2020). The effect of a mindfulness-based therapy on different biomarkers among patients with inflammatory bowel disease: a randomised controlled trial. Scientific Reports, vol. 10, art. 6071 (04 apr.). DOI: https://doi.org/10.1038/s41598-020-63168-4
Resumen : Mindfulness-based interventions have shown some efficacy in decreasing stress levels and improving quality of life. However, so far, only a few studies have studied this type of intervention among patients with inflammatory bowel disease and none of them have studied their effects on inflammatory biomarkers. This current study was a two-armed, single-centre, randomised (2:1 ratio) controlled trial used to evaluate the effects of a mindfulness-based intervention (n = 37) compared to standard medical therapy (n = 20) in patients with Crohn’s disease or ulcerative colitis. The mindfulness intervention blended four internet-based therapy modules with four face-to-face support sessions. The outcomes we assessed were faecal calprotectin (primary outcome), C-reactive protein, and cortisol levels measured in hair samples at several timepoints. The between-group analysis highlighted significant decreases in faecal calprotectin and in C-reactive protein levels in the mindfulness-based intervention group compared to the standard medical therapy group at the six-month follow-up (faecal calprotectin: −367, [95% CI: −705, −29], P = 0.03; C-reactive protein: −2.82, [95% CI: −5.70, 0.08], P = 0.05), with moderate to large effect sizes (faecal calprotectin: ηp2 = 0.085; C-reactive protein: ηp2 = 0.066). We concluded that mindfulness-based therapy administered as part of standard clinical practice effectively improves inflammatory biomarkers in patients diagnosed with inflammatory bowel disease.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://www.nature.com/articles/s41598-020-63168-4.pdf
URI : http://hdl.handle.net/10637/12648
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2045-2322 (Electrónico).
Aparece en las colecciones: Dpto. Medicina y Cirugía

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