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dc.contributor.otherProducción Científica UCH 2020-
dc.contributor.otherUCH. Departamento de Medicina y Cirugía-
dc.creatorGarde Noguera, Javier.-
dc.creatorFernández Murga, María Leonor.-
dc.creatorGiner Bosch, Vicent.-
dc.creatorDomínguez Márquez, Ma. Victoria.-
dc.creatorGarcía Sánchez, José.-
dc.creatorSoler Cataluña, Juan José.-
dc.date2020-
dc.date.accessioned2021-05-12T04:00:27Z-
dc.date.available2021-05-12T04:00:27Z-
dc.date.issued2020-11-25-
dc.identifier.citationGarde-Noguera, J., Fernández-Murga, M.L., Giner-Bosch, V., Dominguez-Márquez, V., Sánchez, J.G., Soler-Cataluña, J.J. et al. (2020). Impact of SARS-CoV-2 infection on patients with cancer: retrospective and transversal studies in Spanish population. Cancers, vol. 12, i. 12 (25 nov.), art. 3513. DOI: https://doi.org/10.3390/cancers12123513-
dc.identifier.issn2072-6694 (Electrónico).-
dc.identifier.urihttp://hdl.handle.net/10637/12598-
dc.descriptionEste artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2072-6694/12/12/3513-
dc.descriptionEn este artículo también participan: Franscica López Chuliá, Beatriz Honrubia, Nuria Piera y Antonio Llombart-Cussac.-
dc.description.abstractBackground: Studies of patients with cancer a ected by coronavirus disease 2019 (COVID-19) are needed to assess the impact of the disease in this sensitive population, and the influence of di erent cancer treatments on the COVID-19 infection and seroconversion. Material and Methods: We performed a retrospective analysis of all patients hospitalized with RT-PCR positive for COVID-19 in our region to assess the prevalence of cancer patients and describe their characteristics and evolution (Cohort 1). Concurrently, a transversal study was carried out in patients on active systemic cancer treatment for symptomatology and seroprevalence (IgG/IgM by ELISA-method) against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (Cohort 2). Results: A total of 215 patients (Cohort 1) were admitted to hospital with a confirmed COVID-19 infection between February 28 and April 30, 2020, and 17 died (7.9%). A medical record of cancer was noted in 43 cases (20%), 6 of them required Intensive care unit ICU attention (14%), and 7 died (16%). There were thirty-six patients (83%) who tested IgG/IgM positive for SARS-CoV-2. Patients on immunosuppressive therapies presented a lower ratio of seroconversion (40% vs. 8%; p = 0.02). In Cohort 2, 166 patients were included in a symptoms-survey and tested for SARS-CoV-2. Any type of potential COVID-19-related symptom was referred up to 67.4% of patients (85.9% vs. 48.2% vs. 73.9%, for patients on chemotherapy, immunotherapy and targeted therapies respectively, p < 0.05). The seroprevalence ratio was 1.8% for the whole cohort with no significant di erences by patient or treatment characteristics. Conclusion: Patients with cancer present higher risks for hospital needs for COVID-19 infection. The lack of SARS-CoV-2 seroconversion may be a concern for patients on immunosuppressive therapies. Patients receiving systematic therapies relayed a high rate of potentially COVID-19-related symptoms, particularly those receiving chemotherapy. However, the seroconversion rate remains low and in the range of general population.-
dc.formatapplication/pdf-
dc.languagees-
dc.language.isoen-
dc.publisherMDPI-
dc.relationEste trabajo de investigación ha sido financiado parcialmente por el Ministerio de Ciencia e Innovación del Gobierno de España bajo la beca PID2019-110442GB-I00.-
dc.relation.ispartofCancers, vol. 12, n. 12.-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.es-
dc.subjectCáncer - Quimioterapia.-
dc.subjectCáncer - Pacientes.-
dc.subjectCoronavirus.-
dc.subjectCoronaviruses.-
dc.subjectCancer - Immunotherapy.-
dc.subjectCancer - Chemotherapy.-
dc.subjectCOVID-19 - España.-
dc.subjectCOVID-19 (Disease) - Spain.-
dc.subjectCancer - Patients.-
dc.subjectCáncer - Inmunoterapia.-
dc.subjectSARS-CoV-2 (Virus)-
dc.titleImpact of SARS-CoV-2 infection on patients with cancer : retrospective and transversal studies in Spanish population-
dc.typeArtículo-
dc.identifier.doihttps://doi.org/10.3390/cancers12123513-
dc.relation.projectIDPID2019-110442GB-I00-
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