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http://hdl.handle.net/10637/11651An unprecedented chlorine-containing piperamide from "Piper pseudoarboreum" as potential leishmanicidal agent
| Título : | An unprecedented chlorine-containing piperamide from "Piper pseudoarboreum" as potential leishmanicidal agent |
| Autor : | Flores, Ninoska Ticona H., Juan Carlos Bilbao Ramos, Pablo Dea Ayuela, María Auxiliadora Ruiz Macedo, Juan C. Bazzocchi, Isabel L. Bolás Fernández, Francisco Jiménez Díaz, Ignacio Antonio |
| Materias: | Fitoquímica.; Fitoterapia.; Herbal medicine.; Leishmaniasis - Treatment.; Espectroscopia.; Leishmaniasis - Tratamiento.; Biosíntesis.; Biosynthesis.; Botanical chemistry.; Piperáceas - Uso terapéutico.; Piperaceae - Therapeutic use.; Spectrum analisys. |
| Editorial : | Elsevier. |
| Citación : | Flores, N., Ticona, JC., Bilbao-Ramos, P., Dea-Ayuela, MA., Ruiz Macedo, JC., Bazzocchi, IL. et al.(2019). An unprecedented chlorine-containing piperamide from "Piper pseudoarboreum" as potential leishmanicidal agent. Fitoterapia, vol. 134 (abr.), pp. 340-345. DOI: https://doi.org/10.1016/j.fitote.2019.03.004 |
| Resumen : | A phytochemical investigation of the ethanolic extract of leaves from Piper pseudoarboreum led to the isolation of 3-chlorosintenpyridone 1, an unprecedented chlorinated piperamide, together with the known compounds 2-12. Their structures were established based on 1D and 2D (COSY, ROESY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The proposed biosynthetic pathway of compound 1 is discussed. Compounds 1-12 were tested in vitro for their leishmanicidal potential against promastigote stages of Leishmania amazonensis, L braziliensis, L. guyanensis and L. infantum. Two compounds from this series, the alkamide 1 (IC50 3.4-5.2 μM) and the fatty acid 9 (IC50 18.7- 29.6 μM) displayed higher or similar potency to Miltefosine, used as the reference drug. |
| Descripción : | Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.sciencedirect.com/science/article/abs/pii/S0367326X19300097 This is the peer reviewed version of the following article: Flores, N., Ticona, JC., Bilbao-Ramos, P., Dea-Ayuela, MA., Ruiz Macedo, JC., Bazzocchi, IL. et al.(2019). An unprecedented chlorine-containing piperamide from "Piper pseudoarboreum" as potential leishmanicidal agent. Fitoterapia, vol. 134 (abr.), pp. 340-345, which has been published in final form at https://doi.org/10.1016/j.fitote.2019.03.004 Este es el post-print del siguiente artículo: Flores, N., Ticona, JC., Bilbao-Ramos, P., Dea-Ayuela, MA., Ruiz Macedo, JC., Bazzocchi, IL. et al.(2019). An unprecedented chlorine-containing piperamide from "Piper pseudoarboreum" as potential leishmanicidal agent. Fitoterapia, vol. 134 (abr.), pp. 340-345, que se ha publicado de forma definitiva en https://doi.org/10.1016/j.fitote.2019.03.004 |
| URI : | http://hdl.handle.net/10637/11651 |
| Derechos: | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
| ISSN : | 0367-326X |
| Fecha de publicación : | 1-abr-2019 |
| Centro : | Universidad Cardenal Herrera-CEU |
| Aparece en las colecciones: | Dpto. Farmacia |
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