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Título : An unprecedented chlorine-containing piperamide from "Piper pseudoarboreum" as potential leishmanicidal agent
Autor : Flores, Ninoska.
Ticona H., Juan Carlos.
Bilbao Ramos, Pablo.
Dea Ayuela, María Auxiliadora.
Ruiz Macedo, Juan C.
Bazzocchi, Isabel L.
Bolás Fernández, Francisco.
Jiménez Díaz, Ignacio Antonio.
Materias: Fitoquímica.Fitoterapia.Herbal medicine.Leishmaniasis - Treatment.Espectroscopia.Leishmaniasis - Tratamiento.Biosíntesis.Biosynthesis.Botanical chemistry.Piperáceas - Uso terapéutico.Piperaceae - Therapeutic use.Spectrum analisys.
Fecha de publicación : 1-abr-2019
Editorial : Elsevier.
Citación : Flores, N., Ticona, JC., Bilbao-Ramos, P., Dea-Ayuela, MA., Ruiz Macedo, JC., Bazzocchi, IL. et al.(2019). An unprecedented chlorine-containing piperamide from "Piper pseudoarboreum" as potential leishmanicidal agent. Fitoterapia, vol. 134 (abr.), pp. 340-345. DOI: https://doi.org/10.1016/j.fitote.2019.03.004
Resumen : A phytochemical investigation of the ethanolic extract of leaves from Piper pseudoarboreum led to the isolation of 3-chlorosintenpyridone 1, an unprecedented chlorinated piperamide, together with the known compounds 2-12. Their structures were established based on 1D and 2D (COSY, ROESY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The proposed biosynthetic pathway of compound 1 is discussed. Compounds 1-12 were tested in vitro for their leishmanicidal potential against promastigote stages of Leishmania amazonensis, L braziliensis, L. guyanensis and L. infantum. Two compounds from this series, the alkamide 1 (IC50 3.4-5.2 μM) and the fatty acid 9 (IC50 18.7- 29.6 μM) displayed higher or similar potency to Miltefosine, used as the reference drug.
Descripción : Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.sciencedirect.com/science/article/abs/pii/S0367326X19300097
This is the peer reviewed version of the following article: Flores, N., Ticona, JC., Bilbao-Ramos, P., Dea-Ayuela, MA., Ruiz Macedo, JC., Bazzocchi, IL. et al.(2019). An unprecedented chlorine-containing piperamide from "Piper pseudoarboreum" as potential leishmanicidal agent. Fitoterapia, vol. 134 (abr.), pp. 340-345, which has been published in final form at https://doi.org/10.1016/j.fitote.2019.03.004
Este es el post-print del siguiente artículo: Flores, N., Ticona, JC., Bilbao-Ramos, P., Dea-Ayuela, MA., Ruiz Macedo, JC., Bazzocchi, IL. et al.(2019). An unprecedented chlorine-containing piperamide from "Piper pseudoarboreum" as potential leishmanicidal agent. Fitoterapia, vol. 134 (abr.), pp. 340-345, que se ha publicado de forma definitiva en https://doi.org/10.1016/j.fitote.2019.03.004
URI : http://hdl.handle.net/10637/11651
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN : 0367-326X
Aparece en las colecciones: Dpto. Farmacia

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