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Título : XPO1 gene therapy attenuates cardiac dysfunction in rats with chronic induced myocardial infarction
Autor : García Manzanares, María Dolores.
Tarazón Melguizo, Estefanía.
Ortega, Ana.
Gil Cayuela, Carolina.
Martínez Dolz, Luis.
González Juanatey, José Ramón.
Lago Paz, Francisca.
Portolés Sanz, Manuel.
Roselló Lletí, Esther.
Rivera Otero, Miguel.
Materias: Heart - Ventricles - Diseases - Treatment.Infarto de miocardio - Tratamiento.Eukaryotic cells.Corazón - Ventrículos - Enfermedades - Tratamiento.Myocardial infarction - Treatment.Células eucariotas.
Fecha de publicación : 1-ago-2020
Editorial : Springer Nature.
Citación : García-Manzanares, M., Tarazón, E., Ortega, A., Gil-Cayuela, C., Martínez-Dolz, L., González-Juanatey, JR. et al. (2019). XPO1 gene therapy attenuates cardiac dysfunction in rats with chronic induced myocardial infarction. Journal of Cardiovascular Translational Research, vol. 13, i. 4 (01 aug.), pp. 593-600. DOI: https://doi.org/10.1007/s12265-019-09932-y
Resumen : Transcriptomic signature ofXPO1was highly expressed and inversely related to left ventricular function in ischemic cardiomy-opathy patients. We hypothesized that treatment with AAV9-shXPO1 attenuates left ventricular dysfunction and remodeling in amyocardial infarction rat model. We induced myocardial infarction by coronary ligation in Sprague-Dawley rats (n= 10), whichreceived AAV9-shXPO1 (n= 5) or placebo AAV9-scramble (n= 5) treatment. Serial echocardiographic assessment was per-formed throughout the study. After myocardial infarction, AAV9-shXPO1-treated rats showed partial recovery of left ventricularfractional shortening (16.8 ± 2.8 vs 24.6 ± 4.1%,P< 0.05) and a maintained left ventricular dimension (6.17 ± 0.95 vs 4.70 ±0.93 mm,P< 0.05), which was not observed in non-treated rats. Furthermore, lower levels of EXP-1 (P< 0.05) and lowercollagen fibers and fibrosis in cardiac tissue were observed. However, no differences were found in the IL-6 or TNFR1 plasmalevels of the myocardium of AAV9-shXPO1 rats. AAV9-shXPO1 administration attenuates cardiac dysfunction and remodelingin rats after myocardial infarction, producing the gene silencing ofXPO1.
Descripción : Este es el artículo que se ha publicado de forma definitiva en: https://link.springer.com/article/10.1007/s12265-019-09932-y
URI : http://hdl.handle.net/10637/10854
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 1937-5387.
1937-5395 (Electrónico).
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal

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