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Título : Nitrosative stress in retinal pathologies : review
Autor : Cantó Catalá, Antolín.
Olivar Rivas, Teresa.
Romero Gómez, Francisco Javier.
Miranda Sanz, María.
Materias: Nitric oxide - Therapeutic use.Óxido nítrico - Uso terapéutico.Retina - Enfermedades - Tratamiento.Antioxidants.Retina - Diseases - Treatment.Antioxidantes.
Fecha de publicación : 11-nov-2019
Editorial : MDPI.
Citación : Cantó Catalá, A., Olivar Rivas, T., Romero Gómez, FJ. and Miranda Sanz, M. (2019). Nitrosative stress in retinal pathologies : review. Antioxidants, vol. 8, n. 11 (11 nov.), art. 543. DOI: https://doi.org/10.3390/antiox8110543
Resumen : Nitric oxide (NO) is a gas molecule with diverse physiological and cellular functions. In the eye, NO is used to maintain normal visual function as it is involved in photoreceptor light transduction. In addition, NO acts as a rapid vascular endothelial relaxant, is involved in the control of retinal blood flow under basal conditions and mediates the vasodilator responses of different substances such as acetylcholine, bradykinin, histamine, substance P or insulin. However, the retina is rich in polyunsaturated lipid membranes and is sensitive to the action of reactive oxygen and nitrogen species. Products generated from NO (i.e., dinitrogen trioxide (N2O3) and peroxynitrite) have great oxidative damaging ffects. Oxygen and nitrogen species can react with biomolecules (lipids, proteins and DNA), potentially leading to cell death, and this is particularly important in the retina. This review focuses on the role of NO in several ocular diseases, including diabetic retinopathy, retinitis pigmentosa, glaucoma or age-related macular degeneration (AMD).
Descripción : Este artículo se ha publicado de forma definitiva en: https://www.mdpi.com/2076-3921/8/11/543
Este artículo pertenece al número especial "Antioxidants and Retinal Disease".
URI : http://hdl.handle.net/10637/10797
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2076-3921 (Electrónico)
Aparece en las colecciones: Dpto. Ciencias Biomédicas

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