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Título : Effects of plasma rich in growth factors (PRGF) on biomechanical properties of Achilles tendon repair / Diego López-Nájera ... et al.
Autor : López Nájera, Diego.
Rubio Zaragoza, Mónica.
Sopena Juncosa, Joaquín Jesús.
Alentorn Geli, Eduard.
Cugat Bertomeu, Ramón.
Fernández Sarmiento, José Andrés.
Domínguez Pérez, Juan Manuel.
García Balletbó, Montserrat.
Primo Capella, Víctor J.
Carrillo Poveda, José María.
Materias: Tendón de Aquiles - Regeneración.Blood plasma - Therapeutic use.Crecimiento - Factores - Uso terapéutico.Plasma sanguíneo - Uso terapéutico.Achilles tendon - Biomechanics.Tendón de Aquiles - Heridas y lesiones - Tratamiento.Achilles tendon - Regeneration.Achilles tendon - Wounds and injuries - Treatment.Tendón de Aquiles - Propiedades mecánicas.Growth factors - Therapeutic use.
Fecha de publicación : 1-dic-2016
Editorial : Springer Nature.
Citación : López-Nájera, D., Rubio-Zaragoza, M., Sopena-Juncosa, JJ., Aletorn-Geli, E., Cugat-Bertomeu, R., Fernández-Sarmiento, JA. et al. (2016). Effects of plasma rich in growth factors (PRGF) on biomechanical properties of Achilles tendon repair. Knee Surgery, Sports Traumatology, Arthroscopy, vol. 24 (dec. 2016), n. 12, pp. 3997-4004. DOI: https://doi.org/10.1007/s00167-015-3725-2
Resumen : To assess the biomechanical effects of intra-tendinous injections of PRGF on the healing Achilles tendon after repair in a sheep model. Thirty sheep were randomly assigned into one of the six groups depending on the type of treatment 10 received (PRGF or placebo) and survival time (2, 4 and 8 weeks). The Achilles tendon injury was repaired by suturing the tendinous edges employing a three-loop pulley pattern. A trans-articular external fixation system was then used for immobilization. The PRGF or placebo was administered on a weekly basis completing a maximum of 3 infiltrations. The force, section and tension values were compared between the operated and healthy Achilles tendons across all groups. The PRGF-treated tendons had higher force at eight weeks compared with the placebo group (p=0.007). Between two and four weeks, a significant increase in force in both the PRGF-treated tendon (p=0.0027) and placebo group (p=0.0095) occurred. No significant differences were found for section ratio between PRGF-treated tendons and the placebo group for any of the time periods evaluated. At 2 weeks PRGF-treated tendons had higher tension ratio compared to placebo group tendons (p=0.0143). Both PRGF and placebo treatments significantly improved the force (p<0.001 and p=0.0095, respectively) and tension (p=0.009 and p=0.0039, respectively) ratios at 8 compared to 2 weeks. The application of PRGF increases Achilles tendon repair strength at 8 weeks compared to the use of placebo. The use of PRGF does not modify section and tension ratios compared to placebo at 8 weeks. The tension ratio progressively increases between two and eight weeks compared with the placebo. PRGF can be used in the clinical setting as a complementary therapy to improve the repair strength of acute Achilles tendon ruptures.
Descripción : Esta es la versión pre-print del artículo que se encuentra disponible en la página web de la revista en la siguiente URL: https://link.springer.com/article/10.1007/s00167-015-3725-2
URI : http://hdl.handle.net/10637/10612
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN : 0942-2056
1433-7347 (Electrónico)
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal




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