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dc.contributor.otherUCH. Departamento de Medicina y Cirugía Animal-
dc.creatorVilar, José M.-
dc.creatorRubio Zaragoza, Mónica.-
dc.creatorSpinella, Giuseppe-
dc.creatorCuervo Serrato, Belén-
dc.creatorSopena Juncosa, Joaquín Jesús.-
dc.creatorCugat Bertomeu, Ramón-
dc.creatorGarcía Balletbó, Montserrat-
dc.creatorDomínguez Pérez, Juan Manuel-
dc.creatorGranados Machuca, María del Mar-
dc.creatorTvarijonaviciute, Asta-
dc.creatorCerón Madrigal, José Joaquín-
dc.creatorCarrillo Poveda, José María.-
dc.date2016-
dc.date.accessioned2019-09-25T04:00:30Z-
dc.date.available2019-09-25T04:00:30Z-
dc.date.issued2016-02-17-
dc.identifier.citationVilar, JM., Rubio, M., Spinella, G., Cuervo, J., Sopena, J., Cugat, R. et al.(2016). Serum collagen Type II cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring of dogs with hip osteoarthritis. PLoS ONE, vol. 11, n. 2 (17 feb. 2016), art. e0149472. DOI: https://doi.org/10.1371/journal.pone.0149472-
dc.identifier.issn1932-6203 (Electrónico)-
dc.identifier.urihttp://hdl.handle.net/10637/10602-
dc.descriptionEste artículo se encuentra disponible en la siguiente URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149472-
dc.description.abstractThe aim of this study was to evaluate the use of serum type II collagen cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring in osteoarthritic dogs. For this purpose, a treatment model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich in growth factors was used. This clinical study included 10 dogs with hip osteoarthritis. Both analytes were measured in serum at baseline, just before applying the treatment, and 1, 3, and 6 months after treatment. These results were compared with those obtained from force plate analysis using the same animals during the same study period. Levels of type II collagen cleavage epitope decreased and those of hyaluronic acid increased with clinical improvement objectively verified via force plate analysis, suggesting these two biomarkers could be effective as indicators of clinical development of joint disease in dogs.-
dc.formatapplication/pdf-
dc.language.isoes-
dc.language.isoen-
dc.publisherPLOS.-
dc.relationLa Fundación Garcia Cugat, la cual apoya esta investigación, recibió apoyo económico del Ministerio de Sanidad, Politica e Igualdad de España (EC11-0046).-
dc.relation.ispartofPLoS ONE, vol. 11, n. 2 (17 feb. 2016).-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.es-
dc.subjectHyaluronic acid - Therapeutic use.-
dc.subjectArticulaciones - Enfermedades - Tratamiento.-
dc.subjectJoints - Diseases - Treatment.-
dc.subjectCélulas madre - Uso terapéutico.-
dc.subjectStem cells - Therapeutic use.-
dc.subjectÁcido hialurónico - Uso terapéutico.-
dc.subjectGrowth factors - Therapeutic use.-
dc.subjectPerros - Locomoción.-
dc.subjectDogs - Locomotion.-
dc.subjectOsteoartritis en los perros - Tratamiento.-
dc.subjectOsteoarthritis in dogs - Treatment.-
dc.subjectCrecimiento - Factores - Uso terapéutico.-
dc.titleSerum collagen Type II cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring of dogs with hip osteoarthritis-
dc.typeArtículo-
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0149472-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal




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