Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/10599
Título : Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs / José M. Vilar ... [et al.].
Autor : Vilar, José M.
Morales, Manuel.
Santana, Angelo.
Spinella, Giuseppe.
Rubio Zaragoza, Mónica.
Cuervo Serrato, Belén.
Cugat Bertomeu, Ramón.
Carrillo Poveda, José María.
Materias: Growth factors - Therapeutic use.
Crecimiento - Factores - Uso terapéutico.
Células madre - Uso terapéutico.
Lameness in dogs.
Osteoartritis en los perros.
Osteoarthritis in dogs.
Cojera en los perros.
Stem cells - Therapeutic use.
Fecha de publicación : 2-jul-2013
Editorial : BioMed Central.
Citación : Vilar, JM., Morales, M., Santana, A., Spinella, G., Rubio, M., Cuervo, B. et al. (2013). Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs. BMC Veterinary Research, ol. 9 (2 jul. 2013), art. 131. DOI: https://doi.org/10.1186/1746-6148-9-131
Resumen : Background: Adipose-derived mesenchymal stem cell (ADMSC) therapy in regenerative medicine is a rapidly growing area of research and is currently also being used to treat osteoarthritis (OA). Force platform analysis has been consistently used to verify the efficacy of different therapeutic strategies for the treatment of OA in dogs, but never with AD-MSC. The aim of this study was to use a force platform to measure the efficacy of intraarticular ADMSC administration for limb function improvement in dogs with severe OA. Results: Eight lame dogs with severe hip OA and a control group of 5 sound dogs were used for this study. Results were statistically analyzed to detect a significant increase in peak vertical force (PVF) and vertical impulse (VI) in treated dogs. Mean values of PVF and VI were significantly improved after treatment of the OA groups, reaching 53.02% and 14.84% of body weight, respectively, at day 180, compared with only 43.56% and 12.16% at day 0. Conclusion: This study objectively demonstrated that intraarticular ADMSC therapy resulted in reduced lameness due to OA.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://bmcvetres.biomedcentral.com/articles/10.1186/1746-6148-9-131
URI : http://hdl.handle.net/10637/10599
ISSN : 1746-6148
1746-6148 (Electrónico)
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal




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