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Influence of chemical enhancers and iontophoresis on the in vitro transdermal permeation of Propranolol : evaluation by dermatopharmacokinetics

Título : Influence of chemical enhancers and iontophoresis on the in vitro transdermal permeation of Propranolol : evaluation by dermatopharmacokinetics
Autor : Calatayud Pascual, María Aracely
Sebastián Morelló, María
Balaguer Fernández, Cristina
Delgado Charro, M. Begoña
López Castellano, Alicia Cristina
Merino Sanjuán, Virginia
Materias: Medicamentos - Administración.Propanol - Farmacocinética.Propanol - Pharmacokinetics.Absorción cutánea.Ionization.Ionización.Propanol - Uso terapéutico.Propanol - Therapeutic use.Drugs - Administration.Skin absorption.
Editorial : MDPI
Citación : Calatayud Pascual, MA., Sebastián Morelló, M., Balaguer Fernández, C., Delgado Charro, MB., López Castellano, A. & Merino, V. (2018). Influence of chemical enhancers and iontophoresis on the in vitro transdermal permeation of Propranolol : evaluation by dermatopharmacokinetics. Pharmaceutics, vol. 10, n. 4, art. 265. DOI: https://doi.org/10.3390/pharmaceutics10040265
Resumen : The aims of this study were to assess, in vitro, the possibility of administering propranolol transdermally and to evaluate the usefulness of the dermatopharmacokinetic (DPK) method in assessing the transport of drugs through stratum corneum, using propranolol as a model compound. Four chemical enhancers (decenoic and oleic acid, laurocapram, and R-(+)-limonene) and iontophoresis at two current densities, 0.25 and 0.5 mA/cm2 were tested. R-(+)-limonene, and iontophoresis at 0.5 mA/cm2 were proven to be the most efficient in increasing propranolol transdermal flux, both doubled the original propranolol transdermal flux. Iontophoresis was demonstrated to be superior than the chemical enhancer because it allowed faster delivery of the drug. The DPK method was sufficiently sensitive to detect subtle vehicle-induced effects on the skin permeation of propranolol. The shorter duration of these experiments and their ability to provide mechanistic information about partition between vehicle and skin and diffusivity through skin place them as practical and potentially insightful approach to quantify and, ultimately, optimize topical bioavailability.
Descripción : Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.mdpi.com/1999-4923/10/4/265
En este artículo científico también participan los siguientes autores: María Sebastian Morelló, Cristina Balaguer Fernández, M. Begoña Delgado Charro, Alicia López Castellano and Virginia Merino.
URI : http://hdl.handle.net/10637/10237
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 1999-4923.
Fecha de publicación : 7-dic-2018
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Farmacia





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