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Título : Bevacizumab diminishes inflammation in an acute endotoxin-induced uveitis model / Salvador Mérida, María Sancho-Tello, Inmaculada Almansa, Carmen Desco, Cristina Peris, Mari-Luz Moreno, Vincent M. Villar, Amparo Navea and Francisco Bosch-Morell.
Autor : Mérida Donoso, Salvador.
Sancho Tello, María.
Almansa Frías, María Inmaculada.
Desco Esteban, Ma. Carmen.
Peris Martínez, Cristina.
Moreno, María Luz.
Villar Amigó, Vicente.
Navea Tejerina, Amparo.
Bosch Morell, Francisco.
Materias: Uveítis - Tratamiento.Ojos - Enfermedades - Tratamiento.Bevacizumab - Efectos fisiológicos.Úvea - Efectos de los medicamentos.Bevacizumab - Physiological effect.Uveitis - Treatment.Estrés oxidativo.Farmacología.Pharmacology.Bevacizumab - Efectos secundarios.Oxidative stress.Uvea - Effect of drugs on.Bevacizumab - Side effects.Eyes - Diseases - Treatment.
Fecha de publicación : 7-jun-2018
Citación : Mérida, S., Sancho-Tello, M., Almansa, I., Desco, C., Peris, C., Moreno, ML., Villar, VM., Navea, A. and Bosch-Morell, F. (2018). Bevacizumab diminishes inflammation in an acute endotoxin-induced uveitis model. Frontiers in Pharmacology, vol. 9, art. 649. DOI: https://doi.org/10.3389/fphar.2018.00649
Resumen : Introduction: Uveitis is an eye disease characterized by inflammation of the uvea and an early and exhaustive diagnosis is essential for its treatment. The aim of our study is to assess the potential toxicity and anti-inflammatory efficacy of Bevacizumab in an experimental uveitis model by subcutaneously injecting lipopolysaccharide into Lewis rats and to clarify its mechanism. Material and Methods: Blood–aqueous barrier integrity was assessed 24 h after endotoxin-induced uveitis (EIU) by analyzing two parameters: cell count and protein concentration in aqueous humors. Histopathology of all eye structures was also studied. Enzyme-linked immunosorbent analyses of the aqueous humor samples were performed in order to calculate the diverse chemokine and cytokine protein levels and oxidative stress-related markers were also evaluated. Results: The aqueous humor’s cellular content significantly increased in the group treated with only Bevacizumab, but it had no effect on retina histopathological grading. Nevertheless, the inflammation noted in ocular structures when administering Bevacizumab with endotoxin was mostly prevented since aqueous humor cell content considerably lowered, and concomitantly with a sharp drop in uveal, vitreous, and retina histopathological grading. The values of the multi-faceted cytokine IL-2 also significantly decreased (p < 0.05 vs. endotoxin group), and the protective IL-6 and IL-10 cytokines values rose with related anti-oxidant system recovery (p < 0.05 vs. endotoxin group). Concurrently, some related M1 macrophage chemokines substantially increased, e.g., GRO/KC, a chemokine that also displays any kind of protective role. Conclusion: All these results revealed that 24 h after being administered, Bevacizumab treatment in EIU significantly prevented inflammation in various eye structures and correct results in efficacy vs. toxicity balance were obtained.
Descripción : En Frontiers in Pharmacology. Lausanne (Switzerland) : Frontiers Media. Vol. 9 (june 2018), art. 649.
Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.frontiersin.org/articles/10.3389/fphar.2018.00649/full
URI : http://hdl.handle.net/10637/10086
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 1663-9812.
Aparece en las colecciones: Dpto. Farmacia

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