Human milk bactericidal properties : effect of lyophilization and relation to maternal factors and milk components

dc.centroUniversidad Cardenal Herrera-CEU
dc.contributor.authorSalcedo, Jaime
dc.contributor.authorSilvestre Castelló, María Dolores
dc.contributor.authorGormaz, María
dc.contributor.authorNogarotto, Elisabetta
dc.contributor.authorSilvestre Castelló, Dolores
dc.contributor.authorLópez Mendoza, María Carmen
dc.contributor.otherUCH. Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos
dc.contributor.otherUCH. Departamento de Farmacia
dc.contributor.otherProducción Científica UCH 2015
dc.date.accessioned2024-10-16T10:54:26Z
dc.date.available2024-10-16T10:54:26Z
dc.date.issued2015-04
dc.descriptionEste recurso no está disponible en acceso abierto por política de la editorial.es_ES
dc.description.abstractObjective: Lyophilization appears to be a viable method for storing human milk, assuring no microbiological contamination and preserving its health benefits and antibacterial properties. The aim of the study is to evaluate and compare the effects of different storage methods (lyophilization and freezing at −20°C and −80°C) and maternal factors (gestational length or time postpartum) upon the microbiological contents and bactericidal activity of human milk. The possible relation between bactericidal activity and the content of certain nutrients and functional components is also investigated. Methods: Microbiological content, bactericidal activity, sialic acid, and ganglioside contents, as well as protein, fat, and lactose concentrations were assessed in 125 human milk samples from 65 healthy donors in the Human Milk Bank of La Fe (Valencia, Spain). Results: Lyophilization and storage at −80°C significantly reduced the content of mesophilic aerobic microorganisms and Staphylococcus epidermidis when compared with storage at −20°C. Bactericidal activity was not significantly modified by lyophilization when compared with freezing at either −20°C or −80°C. Bactericidal activity was not correlated with fat, protein, or lactose content, but was significantly correlated to ganglioside content. The bactericidal activity was significantly greater (P < 0.05) in mature milk and in milk from women with term delivery than in milk from early lactation (days 1–7 postpartum) and milk from women with preterm delivery, respectively. Conclusions: Lyophilization and storage at −80°C of human milk yields similar results and are superior to storage at −20C with regard to microbial and bactericidal capacities, being a feasible alternative for human milk banks.es_ES
dc.identifier.citationSalcedo, J., Gormaz, M., López-Mendoza, M.C., Nogarotto, E., & Silvestre, D. (2015). Human milk bactericidal properties : effect of lyophilization and relation to maternal factors and milk components. Journal of Pediatric Gastroenterology and Nutrition, 60(4), 527–532. https://doi.org/10.1097/MPG.0000000000000641es_ES
dc.identifier.doihttps://doi.org/10.1097/MPG.0000000000000641
dc.identifier.issn0277-2116
dc.identifier.issn1536-4801 (Electrónico)
dc.identifier.urihttp://hdl.handle.net/10637/16285
dc.language.isoenes_ES
dc.publisherJohn Wiley & Sonses_ES
dc.relationUCH. Financiación Universidad
dc.relationEste artículo de investigación ha sido financiado por el Banco Santander y por la Universidad CEU Cardenal Herrera (BC/ICB-Santander 13/12 y PRCEU-UCH 38/11).
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition, 60(4)
dc.relation.projectIDBC/ICB-Santander 13/12
dc.relation.projectIDPRCEU-UCH 38/11
dc.rightsrestricted access
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectLeche maternaes_ES
dc.subjectMother's milkes_ES
dc.subjectLactancia maternaes_ES
dc.subjectBreast feedinges_ES
dc.subjectLiofilizaciónes_ES
dc.subjectFreeze-dryinges_ES
dc.titleHuman milk bactericidal properties : effect of lyophilization and relation to maternal factors and milk componentses_ES
dc.typeArtículoes_ES
dspace.entity.typePublicationes
relation.isAuthorOfPublication9737247c-01ed-4b0a-95a2-ed5f5eaa3fb6
relation.isAuthorOfPublication2520e1bb-b810-43e8-bf99-92a793d8c9fc
relation.isAuthorOfPublication.latestForDiscovery9737247c-01ed-4b0a-95a2-ed5f5eaa3fb6

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