Checking whether changes in the perception of the quality of life related to health, after the nursing intervention, influence these patients’ motivation to change. This was a two‐staged study undertaken in entertainment‐sector workers in Spain: the first part was transversal and observational, and the second was semi‐experimental. First part undertook in 284 entertainmentsector workers, selected by non‐probabilistic sampling, while second part undertook in 50 entertainment‐business workers, selected by consecutive sampling from those who consumed substances. A short group‐based motivational intervention session was implemented by nursing staff, and a before and after evaluation was completed. The EuroQol‐5D and Test for the Evaluation of the Quality of Life in Addicts to Psychoactive Substances (TECVASP) were used. The patients’ motivation to change was evaluated through the Stages of Change Readiness and Treatment Eagerness Scale. The results analysis showed that the nursing intervention reduced the participants’ perceptions of their health‐related quality of life (t = 4.23; P = 0.00009) and of their quality of life in addicts to psychoactive substances (t = 3.38; P = 0.00140). There was an increase in the motivation of 6 workers (12%) to seek treatment of their addiction (χ = 13.02; P = 0.0091). The post‐test contemplation stage score was predicted (F = 6.56; P = 0.003; R = 0.46) with post‐test TECVASP score and pre–post difference in TECVASP score. By reducing the patients’ perception of their quality of life, this brief nursing intervention facilitated a favourable increase in the motivation for change among these workers and was effective in 12% of cases.