Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis
| dc.centro | Universidad Cardenal Herrera-CEU | |
| dc.contributor.author | Gaba, Fariah | |
| dc.contributor.author | Sheth Shah, Chirag Chandrakant | |
| dc.contributor.author | Veses Jiménez, Verónica | |
| dc.contributor.other | UCH. Departamento de Ciencias Biomédicas | |
| dc.contributor.other | UCH. Departamento de Medicina (Extinguido) | |
| dc.contributor.other | Producción Científica UCH 2021 | |
| dc.contributor.other | UCH. Departamento de Medicina y Cirugía | |
| dc.date | 2021 | |
| dc.date.accessioned | 2019-09-27T04:00:11Z | |
| dc.date.available | 2019-09-27T04:00:11Z | |
| dc.date.issued | 2021-03-19 | |
| dc.description | Esta es la versión pre-print del artículo, el cual se encuentra disponible en la siguiente URL: https://onlinelibrary.wiley.com/doi/full/10.1111/jop.12791 | |
| dc.description.abstract | More than 90% of malignant tumors of the head and neck are oral squamous cell carcinomas (OSCC). Early OSCC detection using salivary biomarkers could prevent malignant transformations and enhance patient survival. A systematic search in MEDLINE and the Central Register of Controlled Trials and meta-analysis were undertaken to identify the screening potential of 6 salivary biomarkers for early OSCC detection: IL-8, IL1-β, DUSP-1 and S100P mRNAs, miR125a and miR200a microRNAs. The sensitivities of IL-8 (0.41; 95%CI 0.19-0.99), IL1-β (0.26; 95%CI 0.19- 0.99), DUSP-1 (0.61; 95%CI 0.01-0.98), and S100P (0.67; 95%CI 0.32- 0.99) were calculated. Specificities of the biomarkers analyzed were found to be IL-8 (0.69; 95%CI 0.66-0.99), IL1-β (0.47; 95%CI 0.46 - 0.90), DUSP-1 (0.75; 95%CI 0.33-1) and S100P (0.73; 95%CI 0.18-0.99). Early detection of OSCC was best achieved by screening for salivary mRNA DUSP-1 and S100P. Further investigation is required into miRNAs as novel biomarkers | |
| dc.format | application/pdf | |
| dc.identifier.citation | Gaba, FI., Sheth, CC. & Veses, V. (2021). Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis. Journal of Oral Pathology and Medicine, vol. 50, i. 3 (mar.), pp. 299-307. DOI: https://doi.org/10.1111/jop.12791 | |
| dc.identifier.doi | https://doi.org/10.1111/jop.12791 | |
| dc.identifier.issn | 0904-2512 | |
| dc.identifier.issn | 1600-0714 (Electrónico) | |
| dc.identifier.uri | http://hdl.handle.net/10637/10614 | |
| dc.language.iso | es | |
| dc.language.iso | en | |
| dc.publisher | John Wiley & Sons. | |
| dc.relation.ispartof | Journal of Oral Pathology and Medicine (mar. 2021). | |
| dc.rights | open access | |
| dc.rights.cc | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Saliva - Análisis. | |
| dc.subject | Marcadores tumorales. | |
| dc.subject | Cancer cells. | |
| dc.subject | Células cancerosas. | |
| dc.subject | Saliva - Analysis. | |
| dc.subject | Boca - Cáncer. | |
| dc.subject | Mouth - Cancer. | |
| dc.subject | Tumor markers. | |
| dc.title | Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis | |
| dc.type | Artículo | |
| dspace.entity.type | Publication | es |
| relation.isAuthorOfPublication | 8d0b353f-814b-4c35-acf1-72f63213467c | |
| relation.isAuthorOfPublication | 96812722-e6c4-4b69-9a37-9f16cde71444 | |
| relation.isAuthorOfPublication.latestForDiscovery | 8d0b353f-814b-4c35-acf1-72f63213467c |
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