Introduction. Impact and adjustment to a drainage enterostomy are measured mainly through health indicators. Objective. To investigate the relationship between resilience and adaptation to the placement of a drainage enterostomy. Methodology. Prospective observational study with a sample of 125 patients (64 men / 36 women) with a temporary or permanent drainage enterostomy and a mean age of 66.72 years. Results. High quality of life (mean 80.5) and resilience (mean 79.57) scores and a positive relationship between both were found. There seems to be a positive relationship with general QL and HRQL. The logistic regression model shows that the main predictor as regards HRQL is resilience.