A pharmacological update of ellagic acid

dc.centroUniversidad Cardenal Herrera-CEU
dc.contributor.authorRíos Cañavate, José Luises
dc.contributor.authorGiner Pons, Rosa Maríaes
dc.contributor.authorRecio Iglesias, María Carmenes
dc.contributor.authorMarín Vázquez, Marta
dc.contributor.otherProducción Científica UCH 2018
dc.contributor.otherUCH. Departamento de Farmacia
dc.date2018es
dc.date.accessioned2019-03-05T05:00:29Z
dc.date.available2019-03-05T05:00:29Z
dc.date.issued2018-10-05
dc.descriptionEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.thieme-connect.com/products/ejournals/pdf/10.1055/a-0633-9492.pdfes
dc.descriptionThis is a pre-print of an article published in Ríos, JL., Giner, RM., Marín, M. and Recio, MC. (2018). A pharmacological update of ellagic acid. Planta Medica, vol. 84, n. 15, pp. 1068-1093. The final authenticated version is available online at: https://doi.org/10.1055/a-0633-9492
dc.descriptionEste es el pre-print del siguiente artículo Ríos, JL., Giner, RM., Marín, M. and Recio, MC. (2018). A pharmacological update of ellagic acid. Planta Medica, vol. 84, n. 15, pp. 1068-1093 que se ha publicado de forma definitiva en https://doi.org/10.1055/a-0633-9492
dc.description.abstractEllagic acid is a common metabolite present in many medicinal plants and vegetables. It is present either in free form or as part of more complex molecules (ellagitannins), which can be metabolized to liberate ellagic acid and several of its metabolites, including urolithins. While ellagic acidʼs antioxidant properties are doubtless responsible for many of its pharmacological activities, other mechanisms have also been implicated in its various effects, including its ability to reduce the lipidemic profile and lipid metabolism, alter pro-inflammatory mediators (tumor necrosis factor-α, interleukin-1β, interleukin-6), and decrease the activity of nuclear factor-κB while increasing nuclear factor erythroid 2-related factor 2 expression. These events play an important role in ellagic acidʼs anti-atherogenic, anti-inflammatory, and neuroprotective effects. Several of these activities, together with the effect of ellagic acid on insulin, glycogen, phosphatases, aldose reductase, sorbitol accumulation, advanced glycation end-product formation, and resistin secretion, may explain its effects on metabolic syndrome and diabetes. In addition, results from recent research have increased the interest in ellagic acid, both as a potential protective agent of the liver and skin and as a potential anticancer agent, due to the specific mechanisms affecting cell proliferation, apoptosis, DNA damage, and angiogenesis and its aforementioned anti-inflammatory properties. Taken together, these effects make ellagic acid a highly interesting compound that may contribute to different aspects of health; however, more studies are needed, especially on the compoundʼs pharmacokinetic profile. In this review, we selected papers published from 2005 to the present.
dc.formatapplication/pdfes
dc.identifier.citationRíos, JL., Giner, RM., Marín, M. and Recio, MC. (2018). A pharmacological update of ellagic acid. Planta Medica, vol. 84, n. 15, pp. 1068-1093. DOI: https://doi.org/10.1055/a-0633-9492
dc.identifier.doihttps://doi.org/10.1055/a-0633-9492
dc.identifier.issn0032-0943.
dc.identifier.urihttp://hdl.handle.net/10637/10061
dc.language.isoenes
dc.publisherGeorg Thieme Verlag KG
dc.relation.ispartofPlanta Medica, vol. 84 (october 2018), n. 15
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectEllagic acid - Pharmacokinetics.es
dc.subjectÁcido elágico - Efectos fisiológicos.es
dc.subjectEllagic acid - Physiological effect.es
dc.subjectAntioxidantes.es
dc.subjectMetabolismo - Trastornos.es
dc.subjectProteína quinasa.es
dc.subjectMetabolism - Disorders.es
dc.subjectProtein kinases.es
dc.subjectÁcido elágico - Farmacocinética.es
dc.subjectAntioxidants.es
dc.titleA pharmacological update of ellagic acides
dc.typeArtículoes
dspace.entity.typePublicationes
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU
europeana.isShownAthttp://hdl.handle.net/10637/10061
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/707854/thumb_europeana/707854.jpg
europeana.providerHispana
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/
europeana.typeTEXT
relation.isAuthorOfPublication9b4a0727-31c6-4cf9-baa5-203f13f5e6b9
relation.isAuthorOfPublication.latestForDiscovery9b4a0727-31c6-4cf9-baa5-203f13f5e6b9

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Pharmacological_Rios_PM_2018_preprint.pdf
Size:
27.68 MB
Format:
Adobe Portable Document Format

Collections