Genome hypermobility by lateral transduction

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dc.centroUniversidad Cardenal Herrera-CEU
dc.contributor.authorChen, John
dc.contributor.authorQuiles Puchalt, Nuria
dc.contributor.authorChiang, Yin Ning
dc.contributor.authorBacigalupe, Rodrigo
dc.contributor.authorFillol Salom, Alfred
dc.contributor.authorChee, Melissa Su Juan
dc.contributor.otherUCH. Departamento de Ciencias Biomédicas
dc.date.accessioned2024-01-31T13:05:08Z
dc.date.available2024-01-31T13:05:08Z
dc.date.issued2018-10-12
dc.descriptionEste recurso no está disponible en acceso abierto por política de la editorial.
dc.description.abstractGenetic transduction is a major evolutionary force that underlies bacterial adaptation.Here we report that the temperate bacteriophages ofStaphylococcusaureusengage in adistinct form of transduction we term lateral transduction. Staphylococcal prophagesdo not follow the previously described excision-replication-packaging pathway but insteadexcise late in their lytic program. Here, DNA packaging initiates in situ from integratedprophages, and large metameric spans including several hundred kilobases of theS.aureusgenome are packaged in phage heads at very high frequency. In situ replication beforeDNA packaging creates multiple prophage genomes so that lateral-transducing particles formduring normal phage maturation, transforming parts of theS.aureuschromosome intohypermobile regions of gene transfer.es_ES
dc.identifier.citationChen, J., Quiles-Puchalt, N., Chiang, Y.N., Bacigalupe, R., Fillol-Salom, A., Chee, M.S.J., Fitzgerald, J.R. & Penadés, J.R. (2018). Genome hypermobility by lateral transduction. Science, vol. 362, i. 6411 (oct.), pp. 207–212. DOI: https://doi.org/10.1126/science.aat5867es_ES
dc.identifier.doihttps://doi.org/10.1126/science.aat5867
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203 (Electrónico)
dc.identifier.urihttp://hdl.handle.net/10637/15246
dc.language.isoenes_ES
dc.publisherAmerican Association for the Advancement of Sciencees_ES
dc.relationEste artículo de investigación ha sido financiado parcialmente por el Ministerio de Educación del Gobierno de Singapur (T1-2015Sep-13), por el National Medical Research Council (BNIG15may013) y por la National University of Singapore (start-up funds), por el Biotechnology and Biological Sciences Research Council (UK) (BB/I013873/1 y BBS/E/D/20002173), por el Medical Research Council (UK) (MR/M003876/1), por el Biotechnology and Biological Sciences Research Council (BBSRC, UK) (BB/N002873/1), por el ERC-ADG-2014 Proposal n° 670932 Dut-signal (de la EU) y por la Wellcome Trust (201531/Z/16/Z).
dc.relation.ispartofScience, vol. 362, i. 6411 (oct.)
dc.relation.projectIDT1-2015Sep-13
dc.relation.projectIDBB/I013873/1
dc.relation.projectIDBBS/E/D/20002173
dc.relation.projectIDMR/M003876/1
dc.relation.projectIDBB/N002873/1
dc.relation.projectID201531/Z/16/Z
dc.rightsrestricted access
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectBacteriófagoses_ES
dc.subjectBacteriophageses_ES
dc.subjectCélulaes_ES
dc.subjectCellses_ES
dc.subjectEstafilococoses_ES
dc.subjectStaphylococcuses_ES
dc.subjectGenéticaes_ES
dc.subjectGeneticses_ES
dc.subjectCromosomases_ES
dc.subjectChromosomeses_ES
dc.subjectVirologíaes_ES
dc.subjectVirologyes_ES
dc.subjectBiología moleculares_ES
dc.subjectMolecular biologyes_ES
dc.titleGenome hypermobility by lateral transductiones_ES
dc.typeArtículoes_ES
dspace.entity.typePublicationes
relation.isAuthorOfPublication0c0506dc-1088-431a-97bb-13c7cc6cbe48
relation.isAuthorOfPublication.latestForDiscovery0c0506dc-1088-431a-97bb-13c7cc6cbe48

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