2. Universidad Cardenal Herrera-CEU

Background: Patient safety is essential in small animal anaesthesia. Thisstudy aimed to assess anaesthesia-related deaths in cats worldwide, identifyrisk and protective factors and provide insights for clinical practice.Methods: A prospective multicentre cohort study of 14,962 cats from198 veterinary centres across different countries was conducted. Data onanaesthesia-related deaths, from premedication up to 48 hours postex-tubation, were collected. Logistic regression was used to analyse patientdemographics, American Society of Anesthesiologists (ASA) classification,procedure type and anaesthetic drugs.Results: The anaesthesia-related mortality was 0.63%, with 74.5% of deathsoccurring postoperatively. Cats with cachexia, a higher ASA status or whounderwent abdominal, orthopaedic/neurosurgical or thoracic proceduresexhibited elevated mortality. Mechanical ventilation use was associated withincreased mortality. Mortality odds were reduced by the use of alpha2 -agonistsedatives, pure opioids in premedication and locoregional techniques.Limitations: Limitations include non-randomised sampling, potentialbiases, unquantified response rates, subjective death cause classification andlimited variable analysis.Conclusions: Anaesthetic mortality in cats is significant, predominantlypostoperative. Risk factors include cachexia, higher ASA status, specificprocedures and mechanical ventilation. Protective factors include alpha2 -agonist sedatives, pure opioids and locoregional techniques. These findingscan help improve anaesthesia safety and outcomes. However, further researchis required to improve protocols, enhance data quality and minimise risks.

Background: In modern times, horses are utilized not only for labour and transportation purposes but also for recreational activities such as competition and pleasure riding. In these various pursuits, the role of vision plays a crucial role. Electroretinography is the most used test to diagnose diseases of the retinal outer segment. There is a wide variety of devices to perform the electroretinography differing one from each other in the corneal electrode and the light stimulation. The Koijman electrode has been tested in dogs but not in horses. The main purpose of this study was to compare electroretinography parameters from horses sedated with detomidine alone or in combination with butorphanol, during a standardized protocol using the Koijman electrode and RETI-port® system. Seven mares were allocated to the detomidine and detomidine plus butorphanol group in a randomised, controlled, crossover study. Friedman and Willcoxon-signed ranked tests were used to compare the electroretinogram parameters. A Student's t-test was used to compare differences in the number of artefacts to valid values ratio obtained under both sedation protocols. Results: Dark adaptation peaked after 16 min under scotopic conditions in both groups. No significant differences in electroretinogram parameters between groups were observed. During the mixed rod and cone response evaluation under scotopic conditions, all mares made a movement of the head resulting in a high number of artefacts. The detomidine plus butorphanol group showed a non-significant tendency to have fewer artefacts and a longer duration of sedation compared to the detomidine group. Conclusions: Detomidine alone or combined with butorphanol may be suitable to use Koijman electrode and the RETI-port® to perform a standardized long protocol in horses with some adaptations.

Background:Ensuring patient safety during small animal anaesthesia is cru-cial. This study aimed to assess anaesthetic-related deaths in dogs globally,identify risks and protective factors and inform clinical practice.Methods:This prospective cohort multicentric study involved 55,022 dogsfrom 405 veterinary centres across various countries. Data on anaesthesia-related deaths from premedication to 48 hours post-extubation werecollected. Logistic regression was used to analyse patient demographics,American Society of Anesthesiologists (ASA) classification, procedure typeand anaesthetic drugs used.Results:Anaesthetic-related mortality was 0.69%. Most deaths occurred post-operatively (81%). Age, obesity and a higher ASA classification score wereassociated with increased mortality. Urgent procedures, non-urgent butunscheduled anaesthesias and short procedures also had higher mortality.Some sedatives, systemic analgesics, hypnotics and the use of locoregionalanaesthesia were linked to a decrease in mortality.Limitations:The limitations of the study include the non-randomised sam-ple, potential selection bias, lack of response rate quantification, variable dataquality control, subjectivity in classifying causes of death and limited analysisof variables.Conclusion:Careful patient evaluation, drug selection and monitoring canbe associated with reduced mortality. These findings can be used to developguidelines and strategies to improve patient safety and outcomes. Furtherresearch is needed to refine protocols, enhance data quality systems andexplore additional risk mitigation measures.