1. Investigación

El objetivo es estudiar la asociación entre la aterosclerosis subclínica y la presencia de los parámetros plasmáticos relacionados con la disfunción del adipocito y el endotelio vascular, en sujetos no fumadores con SM, menores de 60 años y sin eventos cardiovasculares previos. Y las conclusiones que se obtienen son que nuestros resultados objetivan que el aumento de los niveles de ICAM-1, VCAM-1 y PAI-1 conlleva un desequilibrio proinflamatorio que se asocia con la presencia de aterosclerosis subclínica. Por tanto, la determinación de sus niveles plasmáticos puede ser de gran utilidad clínica y mejorar la estratificación del riesgo de ECV en sujetos no fumadores en estadios tempranos de SM, más allá de los marcadores tradicionales de riesgo cardiovascular.

Background and Objective: Arterial Stiffness (AS) measured as pulse wave velocity has emerged in recent years as a hypertension mediated organ damage with independent prognostic value for Cardiovascular (CV) diseases that has also been discussed as a potential cause of Hypertension (HTN). The aim of this study is to (1) evaluate how measurement of AS modifies CV risk calculation by SCORE, (2) to measure the predictive value of AS for incident hypertension in normotensive patients, and (3) to analyze the association between control of HTN and presence of AS in sustained HTN. Patients and Methods: A longitudinal, prospective, observational trial under conditions of daily pharmaceutical and clinical practice will be conducted in approximately 60 community pharmacies of the Iberian Peninsula in normotensive and/or hypertensive patients entering a pharmacy spontaneously. In the first cross-sectional step, AS will be estimated with a semiautomatic, validated device (Mobil-O-Graph®, IEM), followed by a 10-item questionnaire. The patients will be referred to Primary Care for stratifying risk by SCORE tables and standard evaluation. In the second longitudinal step, patients will be asked to repeat the visit after 12 months. Discussion: This study aims to improve CV risk stratification and to investigate the potential of AS in predicting incident HTN in normotensive subjects. Besides, it will analyze the role of arterial stiffness as an associated factor to prevent control in sustained HTN in a setting of cooperation between community pharmacies and physicians in daily clinical practice.