Metsämarttila, ErjaRodilla Sala, EnriqueJokelainen, JariHerrala, SauliLeppäluoto, JuhaniKeinänen-Kiukaanniemi, SirkkaHerzig, Karl-HeinzUCH. Departamento de Medicina (Extinguido)Producción Científica UCH 2018UCH. Departamento de Medicina y Cirugía2019-07-092019-07-092018-05-23Metsamarttila, E., Rodilla, E., Jokelainen, J., Herrala, S., Leppaluoto, J., Keinanen-Kiukaanniemi, S. et al. (2018). Effect of physical activity on pulse wave velocity in elderly subjects with normal glucose, prediabetes or Type 2 Diabetes. Scientific Reports, vol. 8, art. 8045. DOI: https://doi.org/10.1038/s41598-018-25755-42045-2322.http://hdl.handle.net/10637/10519Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.nature.com/articles/s41598-018-25755-4Este artículo fue presentado en parte en el 77th Scientific Sessions of the American Diabetes Association, June 9-13, 2017, San Diego, California, USA.Carotid-femoral pulse wave velocity ((cf)PWV) is a measure of arterial stiffness, predicting cardiovascular disease. We hypothesized that the amount of physical activity (PA) is correlated with reduced arterial stiffness in Type 2 diabetic (T2D) subjects. 570 subjects from the 1945 Oulu birth cohort were included in the analysis. (cf)PWV was determined by a non-invasive applanation tonometry. Oral glucose tolerance test was performed and LDL and HDL cholesterol analyzed. PA was registered daily with a wrist-worn acceleration meter for two weeks. (cf)PWV values in subjects with impaired glucose metabolism (IGM) and T2D were higher than in normal glycemic subjects (P < 0.001). PA, fasting and 2 h glucose and HbA1c correlated significantly with (cf)PWV, but HDL or LDL cholesterol did not. The 2 h glucose, heart rate and alcohol consumption in T2D subjects had independent effects on (cf)PWV in multiple regression analysis. T2D and IGM were significantly associated to (cf)PWV. Interestingly, lipids did not have an additional effect on (cf)PWV. Subjects walking more than 10 000 steps/day had 0.2 m/s lower (cf)PWV than those walking less than 6000 steps/day. Presence of T2D, elevated heart rate and alcohol consumption in males were associated with increased aortic stiffening in elderly subjects.application/pdfenopen accessExercise - Physiological aspects.Ejercicio físico - Aspectos fisiológicos.Diabetes.Blood pressure - Measurement.Enfermedades cardiovasculares - Factores de riesgo.Ritmo cardíaco - Medición.Pulse - Mensuration.Presión sanguínea - Medición.Cardiovascular system - Diseases - Risk factors.Pulso - Medición.Artículohttps://doi.org/10.1038/s41598-018-25755-4http://creativecommons.org/licenses/by/4.0/deed.eshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es