Redondo Martínez, FernandoSáez Álvarez, YaniraCuéllar, CarmenMagnet, AngelaGalindo-Regal, LorenaUribe Quintana, NataliaLópez-Bañeres, ManuelJiménez, Ana IsabelLlombart-Cussac, AntonioÁguila de la Puente, Carmen delAndreu-Ballester, Juan CarlosHurtado Marcos, CarolinaIzquierdo Arias, FernandoMagnet Dávila, AngelaFenoy Rodríguez, María SoledadUniversidad San Pablo-CEU. Facultad de Farmacia. Departamento de Ciencias Farmacéuticas y de la SaludGrupo: Parasitología e Inmunología molecular con aplicación biotecnológica, diagnóstica y terapéutica (PARINM)2024-01-242024-01-242022-10-29Redondo F, Hurtado-Marcos C, Izquierdo F, Cuéllar C, Fenoy S, Sáez Y, Magnet Á, Galindo-Regal L, Uribe N, López-Bañeres M, Jiménez AI, Llombart-Cussac A, Del Águila C, Andreu-Ballester JC. Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients. Cancers (Basel). 2022 Oct 29;14(21):5342. doi: 10.3390/cancers14215342. PMID: 36358760; PMCID: PMC96588662072-6694http://hdl.handle.net/10637/15102Microsporidia are opportunistic intracellular parasites, generating serious pathology in individuals with a compromised immune system. Infection by microsporidia inhibits p53 and Caspase 3, proteins involved in apoptosis and the cell cycle, which are vital in the malignant process of epithelial cells. The presence of microsporidia in the intestinal tissues of 87 colon cancer (CC) patients and 25 healthy controls was analyzed by real-time PCR and an immunofluorescence antibody test. Anti-Encephalitozoon antibodies were analyzed in serum samples by ELISA (enzyme linked immunosorbent assay). In 36 (41.3%) CC cases, microsporidia infections were identified in their tissues vs. no cases among control subjects (p < 0.0001). An increase in IgG and IgE anti-Encephalitozoon antibodies was found in patients with CC, which would demonstrate continuous and previous contact with the parasite. The high prevalence of microsporidia in tissues and the seroprevalence in patients with CC suggest a relationship between microsporidia and the etiopathogenesis of CC.application/pdfenopen accessMicrosporidiaEncephalitozoon sp.Enterocytozoon bieneusiColon cancerIFATELISAArtículo10.3390/cancers14215342https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es