Moya, CarlosMáñez Aliño, SalvadorMarín Vázquez, MartaUCH. Departamento de FarmaciaProducción Científica UCH 20192020-03-122020-03-122019-12-05Marín Vázquez, M., Moya, C. and Máñez Aliño, S. (2019). Mutual influences between Nitric Oxide and Paraoxonase 1. Antioxidants, vol. 8, n. 12 (5 dec.), art. 619. DOI: https://doi.org/10.3390/antiox81206192076-3921 (Electrónico)http://hdl.handle.net/10637/10790Este artículo se ha publicado de forma definitiva en: https://www.mdpi.com/2076-3921/8/12/619Este artículo pertenece al número especial "Paraoxonase in Oxidation and Inflammation".One of the best consolidated paradigms in vascular pharmacology is that an uncontrolled excess of oxidizing chemical species causes tissue damage and loss of function in the endothelial and subendothelial layers. The fact that high-density lipoproteins play an important role in preventing such an imbalance is integrated into that concept, for which the expression and activity of paraoxonases is certainly crucial. The term paraoxonase (aryldialkyl phosphatase, EC 3.1.8.1) encompasses at least three distinct isoforms, with a wide variation in substrate a nity, cell and fluid localization, and biased expression of polymorphism. The purpose of this review is to determine the interactions that paraoxonase 1 has with nitric oxide synthase, its reaction product, nitric oxide (nitrogen monoxide, NO), and its derived reactive species generated in an oxidative medium, with a special focus on its pathological implications.application/pdfenopen accessAntioxidantes.Antioxidants.Nitric oxide - Therapeutic use.Paraoxonasa - Uso terapéutico.Lipoproteínas.Vasculitis - Tratamiento.Vasculitis - Treatment.Óxido nítrico - Uso terapéutico.Paraoxonase - Therapeutic use.Lipoproteins.Artículohttps://doi.org/10.3390/antiox8120619https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es