Chen, JohnQuiles Puchalt, NuriaCarpena, NuriaRam, GeetaNovick, Richard P.Penadés Casanova, José RafaelUCH. Departamento de Ciencias Biomédicas2024-01-312024-01-312015-05Chen, J., Carpena, N., Quiles-Puchalt, N., Ram, G., Novick, R. P., & Penadés, J. R. (2015). Intra- and inter-generic transfer of pathogenicity island-encoded virulence genes by cos phages. The ISME Journal, vol. 9, i. 5 (may.), pp. 1260–1263. DOI: https://doi.org/10.1038/ismej.2014.1871751-73621751-7370 (Electrónico)http://hdl.handle.net/10637/15247Este recurso no está disponible en acceso abierto por política de la editorial.Bacteriophage-mediated horizontal gene transfer is one of the primary driving forces of bacterial evolution. The pac-type phages are generally thought to facilitate most of the phage-mediated gene transfer between closely related bacteria, including that of mobile genetic elements-encoded virulence genes. In this study, we report that staphylococcal cos-type phages transferred the Staphylococcus aureus pathogenicity island SaPIbov5 to non-aureus staphylococcal species and also to different genera. Our results describe the first intra- and intergeneric transfer of a pathogenicity island by a cos phage, and highlight a gene transfer mechanism that may have important implications for pathogen evolution.enrestricted accessVirologíaVirologyGenéticaGeneticsEstafilococosStaphylococcusGenómicaGenomicsBacteriófagosBacteriophagesArtículohttps://doi.org/10.1038/ismej.2014.187https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es