Gaba, FariahSheth Shah, Chirag ChandrakantVeses Jiménez, VerónicaUCH. Departamento de Ciencias BiomédicasUCH. Departamento de Medicina (Extinguido)Producción Científica UCH 2021UCH. Departamento de Medicina y Cirugía2019-09-272019-09-272021-03-19Gaba, FI., Sheth, CC. & Veses, V. (2021). Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis. Journal of Oral Pathology and Medicine, vol. 50, i. 3 (mar.), pp. 299-307. DOI: https://doi.org/10.1111/jop.127910904-25121600-0714 (Electrónico)http://hdl.handle.net/10637/10614Esta es la versión pre-print del artículo, el cual se encuentra disponible en la siguiente URL: https://onlinelibrary.wiley.com/doi/full/10.1111/jop.12791More than 90% of malignant tumors of the head and neck are oral squamous cell carcinomas (OSCC). Early OSCC detection using salivary biomarkers could prevent malignant transformations and enhance patient survival. A systematic search in MEDLINE and the Central Register of Controlled Trials and meta-analysis were undertaken to identify the screening potential of 6 salivary biomarkers for early OSCC detection: IL-8, IL1-β, DUSP-1 and S100P mRNAs, miR125a and miR200a microRNAs. The sensitivities of IL-8 (0.41; 95%CI 0.19-0.99), IL1-β (0.26; 95%CI 0.19- 0.99), DUSP-1 (0.61; 95%CI 0.01-0.98), and S100P (0.67; 95%CI 0.32- 0.99) were calculated. Specificities of the biomarkers analyzed were found to be IL-8 (0.69; 95%CI 0.66-0.99), IL1-β (0.47; 95%CI 0.46 - 0.90), DUSP-1 (0.75; 95%CI 0.33-1) and S100P (0.73; 95%CI 0.18-0.99). Early detection of OSCC was best achieved by screening for salivary mRNA DUSP-1 and S100P. Further investigation is required into miRNAs as novel biomarkersapplication/pdfesopen accessSaliva - Análisis.Marcadores tumorales.Cancer cells.Células cancerosas.Saliva - Analysis.Boca - Cáncer.Mouth - Cancer.Tumor markers.Artículohttps://doi.org/10.1111/jop.12791https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es