Corral Pérez, JuanVelázquez Díaz, DanielPérez Rey, AlejandroVázquez Sánchez, María Á.Calderón Domínguez, MaríaCasals, CristinaPonce González, Jesús G.Alcalá Díaz-Mor, MartínUniversidad San Pablo-CEU. Facultad de Farmacia. Departamento de Química y BioquímicaGrupo de Metabolismo y Función Vascular (MET-VASC)2023-07-052023-07-052023-01-04Corral-Pérez, J.; Alcala, M.; Velázquez-Díaz, D.; Perez-Bey, A.; Vázquez-Sánchez, M.Á.; Calderon-Dominguez, M.; Casals, C.; Ponce-González, J.G. Sex-Specific Relationships of Physical Activity and Sedentary Behaviour with Oxidative Stress and Inflammatory Markers in Young Adults. Int. J. Environ. Res. Public Health 2023, 20, 899. https://doi.org/10.3390/ ijerph200208991660-4601http://hdl.handle.net/10637/14502This study aims to analyse sex-specific associations of physical activity and sedentary behaviour with oxidative stress and inflammatory markers in a young-adult population. Sixty participants (21 women, 22.63 4.62 years old) wore a hip accelerometer for 7 consecutive days to estimate their physical activity and sedentarism. Oxidative stress (catalase, superoxide dismutase, glutathione peroxidase, glutathione, malondialdehyde, and advanced oxidation protein products) and inflammatory (tumour necrosis factor-alpha and interleukin-6) markers were measured. Student t-tests and single linear regressions were applied. The women presented higher catalase activity and glutathione concentrations, and lower levels of advanced protein-oxidation products, tumour necrosis factor-alpha, and interleukin-6 than the men (p < 0.05). In the men, longer sedentary time was associated with lower catalase activity (b = 􀀀0.315, p = 0.04), and longer sedentary breaks and higher physical-activity expenditures were associated with malondialdehyde (b = 􀀀0.308, p = 0.04). Vigorous physical activity was related to inflammatory markers in the women (tumour necrosis factor-alpha, b = 0.437, p = 0.02) and men (interleukin􀀀6, b = 0.528, p < 0.01). In conclusion, the women presented a better redox and inflammatory status than the men; however, oxidative-stress markers were associated with physical activity and sedentary behaviours only in the men. In light of this, women could have better protection against the deleterious effect of sedentarism but a worse adaptation to daily physical activity.application/pdfenopen accessAccelerometryAntioxidantsInflammationSedentarismGenderArtículo10.3390/ijerph20020899https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es