Alcaraz Tormo, María JoséCompañ, ÁlvaroGuillén Salazar, IsabelProducción Científica UCH 2020UCH. Departamento de Farmacia2021-05-122021-05-122019-12-31Alcaraz, M.J., Compañ, A. & Guillén, M.I. (2019). Extracellular vesicles from mesenchymal stem cells as novel treatments for musculoskeletal diseases. Cells, vol. 9, i. 1 (31 dec.), art. 98. DOI: https://doi.org/10.3390/cells90100982073-4409 (Electrónico)http://hdl.handle.net/10637/12582Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2073-4409/9/1/98Este artículo pertenece al número especial "Therapeutic applications of extracellular vesicles".Mesenchymal stem/stromal cells (MSCs) represent a promising therapy for musculoskeletal diseases. There is compelling evidence indicating that MSC e ects are mainly mediated by paracrine mechanisms and in particular by the secretion of extracellular vesicles (EVs). Many studies have thus suggested that EVs may be an alternative to cell therapy with MSCs in tissue repair. In this review, we summarize the current understanding of MSC EVs actions in preclinical studies of (1) immune regulation and rheumatoid arthritis, (2) bone repair and bone diseases, (3) cartilage repair and osteoarthritis, (4) intervertebral disk degeneration and (5) skeletal muscle and tendon repair. We also discuss the mechanisms underlying these actions and the perspectives of MSC EVs-based strategies for future treatments of musculoskeletal disorders.application/pdfesopen accessOsteoartritis - Tratamiento.Osteoarthritis - Treatment.Stem cells - Therapeutic use.Sistema musculoesquelético - Enfermedades - Tratamiento.Musculoskeletal system - Diseases - Treatment.Células madre - Uso terapéutico.Artículohttps://doi.org/10.3390/cells9010098https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es