Suso Martí, LuisNúñez Cortés, RodrigoFerrer Sargues, Francisco JoséSánchez Sabater, AlbertoLópez Bueno, RubénCalatayud, JoaquínGarrigós Pedrón, MiriamUCH. Departamento de Ciencias BiomédicasUCH. Departamento de Enfermería y FisioterapiaProducción Científica UCH 20242024-10-312024-10-312024-04Suso-Martí, L., Núñez-Cortés, R., Sánchez-Sabater, A., Garrigós-Pedrón, M., Ferrer-Sargues, F.J., López-Bueno, R., & Calatayud, J. (2024). Effects of exercise-based interventions on inflammatory markers in patients with fibromyalgia: a systematic review and meta-analysis. Seminars in Arthritis and Rheumatism, 65, 152377. https://doi.org/10.1016/j.semarthrit.2024.1523770049-01721532-866X (Electrónico)http://hdl.handle.net/10637/16346This is the peer reviewed version of the following article: Suso-Martí, L., Núñez-Cortés, R., Sánchez-Sabater, A., Garrigós-Pedrón, M., Ferrer-Sargues, F.J., López-Bueno, R., & Calatayud, J. (2024). Effects of exercise-based interventions on inflammatory markers in patients with fibromyalgia: a systematic review and meta-analysis. Seminars in Arthritis and Rheumatism, 65, 152377, which has been published in final form at https://doi.org/10.1016/j.semarthrit.2024.152377Este es el post-print del siguiente artículo: Suso-Martí, L., Núñez-Cortés, R., Sánchez-Sabater, A., Garrigós-Pedrón, M., Ferrer-Sargues, F.J., López-Bueno, R., & Calatayud, J. (2024). Effects of exercise-based interventions on inflammatory markers in patients with fibromyalgia: a systematic review and meta-analysis. Seminars in Arthritis and Rheumatism, 65, 152377, que se ha publicado de forma definitiva en https://doi.org/10.1016/j.semarthrit.2024.152377Objectives: The aim of the present review was (1) to determine the effects of exercise based-interventions (EBIs) on pro-inflammatory and anti-inflammatory biomarkers in patients with fibromyalgia (FM), and (2) to determine the most effective type (acute or maintained) and modality (aerobic, resistance, etc.). Methods: A systematic search was conducted in various electronic databases to identify all the relevant studies: Medline (PubMed), PEDro, EBSCO and Google Scholar. Clinical trials assessing the effects of EBIs in patients with FM were selected. Methodological quality was evaluated by two independent investigators using the Cochrane Risk of Bias Tool. Qualitative analysis was based on the classification of the results into levels of evidence according to GRADE. Results: Eleven studies were included. The meta-analysis showed a statistically significant decrease in proinflammatory biomarkers by EBIs with a large clinical effect in 19 comparisons (SMD: 1.74; 95 % CI: 0.85–2.62; p < 0.05), especially for IL8. The certainty of the evidence was low. The meta-analysis showed no statistically significant increase in anti-inflammatory biomarkers (IL10) by EBIs in 6 comparisons and very low certainty of evidence. Evidence was found for acute and maintained effects of exercise, with aerobic and aquatic exercise modalities showing better improvements than resistance exercise. Conclusions: EBIs are effective in inducing an immunomodulatory response in FM, characterized by decreased pro-inflammatory signaling. However, there was no evidence of an increase in anti-inflammatory biomarkers. These results should be interpreted with caution due to low certainty of evidence.enFibromialgiaFibromyalgiaEducación físicaPhysical educationFIsioterapiaPhysiotherapyInmunologíaImmunologyArtículohttps://doi.org/10.1016/j.semarthrit.2024.152377https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es