Ruíz Gayo, MarianoGarcía Prieto, Concepción F.Somoza Hernández, BeatrizGil Ortega, MartaGrupo de Metabolismo y Función Vascular (MET-VASC)Universidad San Pablo-CEU. Facultad de Farmacia2023-09-202023-09-202013-11-07Fernández-Alfonso MS, Gil-Ortega M, García-Prieto CF, Aranguez I, Ruiz-Gayo M, Somoza B. Mechanisms of perivascular adipose tissue dysfunction in obesity. Int J Endocrinol. 2013;2013:402053. doi: 10.1155/2013/4020531687-8345http://hdl.handle.net/10637/14607En colaboración con: Maria S. Fernández-Alfonso e Isabel AranguezMost blood vessels are surrounded by adipose tissue. Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies. In 1991, Soltis and Cassis demonstrated for the first time that PVAT reduced contractions to noradrenaline in rat aorta. Since then, an important number of adipocyte-derived factors with physiological and pathophysiological paracrine vasoactive effects have been identified. PVAT undergoes structural and functional changes in obesity. During early diet-induced obesity, an adaptative overproduction of vasodilator factors occurs in PVAT, probably aimed at protecting vascular function. However, in established obesity, PVAT loses its anticontractile properties by an increase of contractile, oxidative, and inflammatory factors, leading to endothelial dysfunction and vascular disease.The aim of this review is to focus on PVAT dysfunction mechanisms in obesityapplication/pdfenopen accessBlood vesselsVasculatureNoradrenalineArtículo10.1155/2013/40205310.1155/2013/402053https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es