Sopena Juncosa, Joaquín JesúsCarrillo Poveda, José MaríaChicharro Alcántara, DeborahCuervo Serrato, BelénDamiá Giménez, ElenaLópez Barbeta, SergioVilar, José M.Rubio Zaragoza, MónicaUCH. Departamento de Medicina y Cirugía AnimalProducción Científica UCH 20182019-02-132019-02-132018-09-11Damiá, E., Chicharro, D., Rubio, M., Carrillo, JM., Sopena, J., Cuervo, B., López, S. and Vilar, JM. (2018). Can plasma rich in growth factors be safe for parental use? : a safety study in the canine model. International Journal of Molecular Sciences, vol. 19, n. 9, art. 2701. DOI: https://doi.org/10.3390/ijms190927011422-0067.http://hdl.handle.net/10637/9990Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.mdpi.com/1422-0067/19/9/2701Low invasiveness is the main goal of modern surgery. The use of platelet-rich plasma (PRP) is known to be effective in a variety of applications, such as oral, maxillofacial, orthopedic, dermatologic and cosmetic surgeries. However, a potential ergogenic and carcinogenic effect of PRP derivatives by means of the insulin-like growth factor-1 (IGF-1) pathway has been suggested. Because of this notion, the purpose of this study is to assess the effect of a commercially available PRP-derivative intramuscular injection in the lumbar muscular tissue (local effect) and to determine the IGF-1 blood concentration (systemic effect) on healthy beagle dogs. Local effect was evaluated by computed tomography (CT) scan and echography, and systemic effect was calculated by blood testing on days 0, 14, 28, 42 and 56. No statistically significant changes were observed; thus, PRGF could be considered safe when using therapeutic doses.application/pdfenopen accessBlood plasma - Therapeutic use.Crecimiento - Factores - Uso terapéutico.Plasma sanguíneo - Uso terapéutico.Dogs.Insuline - Therapeutic use - Testing.Insulina - Uso terapéutico - Ensayos clínicos.Perros.Growth factors - Therapeutic use.Artículohttps://doi.org/10.3390/ijms19092701http://creativecommons.org/licenses/by/4.0/deed.eshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es