Ballell, LluísBates, Robert H.2013-11-012013-11-012013-11-01http://hdl.handle.net/10637/5543Artículo en colaboración con : Livia Vivas, Anna Easton, Howard Kendrick, Angus Cameron, David Barros, Federico Gómez de las Heras, R. Leo Brady and Simon L. CroftEn: ChemMedChem. ISSN 1860-7187. n. 8, 2013, págs 313-321With the aim of fuelling open-source, translational, early-stage drug discovery activities, the results of the recently completed antimycobacterial phenotypic screening campaign against Mycobacterium bovis BCG with hit confirmation in M. tuberculosis H37Rv were made publicly accessible. A set of 177 potent noncytotoxic H37Rv hits was identified and will be made available to maximize the potential impact of the compounds toward a chemical genetics/proteomics exercise, while at the same time providing a plethora of potential starting points for new synthetic lead-generation activities. Two additional drug-discovery- relevant datasets are included: a) a drug-like property analysis reflecting the latest lead-like guidelines and b) an early lead-generation package of the most promising hits within the clusters identified.application/pdfenCompuestos heterocíclicos.Artículohttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es