Suay García, BeatrizGalán Sánchez, FátimaRodríguez Iglesias, Manuel A.Pérez Gracia, María TeresaUCH. Departamento de FarmaciaProducción Científica UCH 2019UCH. Departamento de Matemáticas, Física y Ciencias Tecnológicas2020-09-172020-09-172019-02-01Suay-García, B., Galán, F., Rodríguez-Iglesias, MA. & Pérez-Gracia, MT. (2019). Vector-Borne and Zoonotic Diseases, vol. 19, n. 2 (feb.), pp. 115-120. DOI: http://doi.org/10.1089/vbz.2018.23331530-36671557-7759 (Electrónico)http://hdl.handle.net/10637/11660Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.liebertpub.com/doi/10.1089/vbz.2018.2333?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedThis is the pre-peer reviewed version of the following article: Suay-García, B., Galán, F., Rodríguez-Iglesias, MA. & Pérez-Gracia, MT. (2019). Detection and characterization of extended-spectrum Beta-Lactamases-Producing "Escherichia coli" in animals. Vector Borne and Zoonotic Diseases, vol. 19, n. 2, pp. 115-120, which has been published in final form at http://doi.org/10.1089/vbz.2018.2333Este es el pre-print del siguiente artículo: Suay-García, B., Galán, F., Rodríguez-Iglesias, MA. & Pérez-Gracia, MT. (2019). Detection and characterization of extended-spectrum Beta-Lactamases-Producing "Escherichia coli" in animals. Vector Borne and Zoonotic Diseases, vol. 19, n. 2, pp. 115-120, que se ha publicado de forma definitiva en http://doi.org/10.1089/vbz.2018.2333The detection of multi-drug resistant bacteria is a growing problem, however, the role of domesticated animals in the propagation of antimicrobial resistance has barely been studied. The aim of this study was to identify ESBL-producing Escherichia coli strains in domestic animal feces in order to assess their antimicrobial resistance profile and carry out molecular characterization of the ß-lactamases. A total of 325 samples were collected from 8 animal species. Of these, 34 bacterial isolates were identified as E. coli. The antibiotic resistance profile of the E. coli strains was as follows: 100% resistant to amoxicillin, aztreonam, and cephalosporines; 58.8% resistant to nalidixic acid, ciprofloxacin and trimethoprim/sulphamethoxazole; 41.2% resistant to gentamicin and tobramycin; 11.8% resistant and 32.4% intermediate to cefoxitin, 97.1% sensible and 2.9% intermediate to amoxicillin/clavulanate; and 100% sensible to ertapenem, minocycline, imipenem, meropenem, amikacin, nitrofurantoin, phosphomycin and colistin. All 34 E. coli strains met criteria for ESBL production. In total, 46 ß-lactamase genes were detected: 43.5% blaTEM, 30.4% blaCTX-M (23.9% blaCTX-M-1 and 6.5% blaCTX-M-9) and 26.1% blaSHV (17.4% blaSHV-5 and 8.7% blaSHV-12). All the ß-lactamases were found in dogs except for 4 blaSHV found in falcons. No pAmpC genes were found. The high prevalence of ESBL-producing E. coli strains in animals could become a zoonotic transmission vector.application/pdfenopen accessDomestic animals.Animals as carriers of disease.Zoonosis.Zoonoses.Bacterias - Resistencia a los medicamentos.Animales vectores.Animales domésticos.Escherichia coli - Resistencia a los medicamentos.Escherichia coli - Drug resistance.Farmacología molecular.Molecular pharmacology.Drug resistance in microorganisms.Artículohttp://doi.org/10.1089/vbz.2018.2333https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es