Bocos de Prada, CarlosDonis Rodríguez, CristinaFauste Alonso, ElenaRodríguez, LourdesRodrigo, SilviaÁlvarez Millán, Juan JoséOtero Gómez, PaolaPanadero Antón, María IsabelPérez Armas, MadelínUniversidad San Pablo-CEU. Facultad de Farmacia. Departamento de Química y Bioquímica2024-01-182024-01-182023-01Fauste, E., Donis, C., Pérez-Armas, M., Rodríguez, L., Rodrigo, S., Álvarez-Millán, J. J., ... & Bocos, C. (2023). Maternal fructose boosts the effects of a Western-type diet increasing SARS-COV-2 cell entry factors in male offspring. Journal of Functional Foods, 100, 105366.Fauste, E., Donis, C., Pérez-Armas, M., Rodríguez, L., Rodrigo, S., Álvarez-Millán, J. J., ... & Bocos, C. (2023). Maternal fructose boosts the effects of a Western-type diet increasing SARS-COV-2 cell entry factors in male offspring. Dataset]. Depósito digital en CEU ReI, http://hdl.handle.net/10637/149492214-9414http://hdl.handle.net/10637/14949Se adjuntan datos de investigación y fichero Readme.txtFructose-rich beverages and foods consumption correlates with the epidemic rise in cardiovascular disease, diabetes and obesity. Severity of COVID-19 has been related to these metabolic diseases. Fructose-rich foods could place people at an increased risk for severe COVID-19. We investigated whether maternal fructose intake in offspring affects hepatic and ileal gene expression of proteins that permit SARS-CoV2 entry to the cell. Carbohydrates were supplied to pregnant rats in drinking water. Adult and young male descendants subjected to water, liquid fructose alone or as a part of a Western diet, were studied. Maternal fructose reduced hepatic SARS-CoV2 entry factors expression in older offspring. On the contrary, maternal fructose boosted the Western diet-induced increase in viral entry factors expression in ileum of young descendants. Maternal fructose intake produced a fetal programming that increases hepatic viral protection and, in contrast, exacerbates fructose plus cholesterolinduced diminution in SARS-CoV2 protection in small intestine of progeny.application/pdfenopen accessFructoseFetal programmingSARS-CoV-2LiverIleumCholesterolArtículo10.1016/j.jff.2022.105366https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es