Fabregat Safont, DavidBaquero Escribano, AbelIbáñez Martínez, MaríaSancho Llopis, Juan VicenteHernández Hernández, FélixHaro Cortés, Gonzalo RafaelUCH. Departamento de Medicina y CirugíaProducción Científica UCH 20202021-11-232021-11-232020-07-01Fabregat-Safont, D., Ibáñez, M., Baquero, A., Sancho, JV., Hernández, F. & Haro, G. (2020). Investigation on the consumption of synthetic cannabinoids among teenagers by the analysis of herbal blends and urine samples. Journal of Pharmaceutical and Biomedical Analysis, vol. 186, art. 113298 (jul.). DOI: https://doi.org/10.1016/j.jpba.2020.1132980731-7085http://hdl.handle.net/10637/13194Este artículo se encuentra disponible en la siguiente URL: https://www.sciencedirect.com/science/article/abs/pii/S073170852030282X?via%3DihubThis is the pre-peer reviewed version of the following article: Fabregat-Safont, D., Ibáñez, M., Baquero, A., Sancho, JV., Hernández, F. & Haro, G. Investigation on the consumption of synthetic cannabinoids among teenagers by the analysis of herbal blends and urine samples. Journal of Pharmaceutical and Biomedical Analysis, vol. 186, art. 113298 (jul. 2020), which has been published in final form at https://doi.org/10.1016/j.jpba.2020.113298Este es el pre-print del siguiente artículo: Fabregat-Safont, D., Ibáñez, M., Baquero, A., Sancho, JV., Hernández, F. & Haro, G. Investigation on the consumption of synthetic cannabinoids among teenagers by the analysis of herbal blends and urine samples. Journal of Pharmaceutical and Biomedical Analysis, vol. 186, art. 113298 (jul. 2020), que se ha publicado de forma definitiva en https://doi.org/10.1016/j.jpba.2020.113298Background: Synthetic cannabinoids (SC) are difficult to detect in urine samples, and therefore an appropriate strategy is required to investigate its potential consumption. In this work, we have designed a study to investigate SCs consumption by minors in juvenile offenders’ centres. Methods: 127 minors were selected from five juvenile offenders’ centres in the Valencian Autonomous Community (Spain). 667 urine samples were collected after their therapeutic permits with stay at home. We studied the active molecules from 7 herbal blends available at the smartshop frequented by minors. Both, the herbal blends and urine samples were analysed by liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry. Results: Regarding cannabis consumption, 40.2% (N=51) of the subjects reported using organic or synthetic cannabis: 5.9% of them reported only to consume synthetic cannabis, 37.2% synthetic and organic cannabis and 56.9% only organic cannabis. The urine samples analysis revealed the absence of the parent SCs investigated, but the presence of the main metabolites from two SCs (XLR-11, UR-144): N-pentanoic acid and N-(5-hydroxypentyl). The 16 individual urine samples positives to the XLR-11 metabolites could be assigned to 6 minors, 2 of which recognize consumption whereas the remaining 4 adolescents did not recognize consumption of SCs. Conclusions: Synthetic cannabinoids, specifically, XLR-11, are consumed in juvenile offenders’ centres in the Autonomous Valencian Community. Preventive and therapeutic interventions in minors housed in those centres must be implemented to reduce the consumption of new psychoactive substances and to improve the risk-perception of these substances.application/pdfesopen accessAdolescentes - Consumo de drogas.Teenagers - Drug use.Cannabis sativa consumption.Orina - Análisis.Cannabis - Consumo.Urine - Analysis.Artículohttps://doi.org/10.1016/j.jpba.2020.113298https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es