Marín García, Pablo JesúsLlobat Bordes, Maria DoloresProducción Científica UCH 2022UCH. Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos2023-03-252023-03-252022-06-20Marín-García, P. J. & Llobat, L. (2022). Canine cytokines profile in an endemic region of L. infantum: related factors. Veterinary Sciences, vol. 9, i. 6 (20 jun.), art. 305. DOI: https://doi.org/10.3390/vetsci90603052306-7381 (Electrónico)http://hdl.handle.net/10637/14170Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2306-7381/9/6/305Canine leishmaniosis is caused by infection with parasite Leishmania infantum, which are transmitted by sandflies Phlebotomus. Canine leishmaniosis is an endemic disease in the Mediterranean region. The immune response could vary between hosts and determines the severity of the disease and clinical features. The aim of this study was to analyze the serum levels of cytokines TNF- , IFN- , IL-2, IL-6, and IL-8, which are related to the activation of Th1 or Th2 immune responses in dogs living in the L. infantum endemic region. Moreover, we intend to relate and correlate these levels with different factors, such as sex, age, diet, lifestyle, and breed. Epidemiological data and serum were recovered for seventy-eight dogs, and serum levels of cytokines described previously were analyzed by using the ELISA method. The results showed differences in serum levels of IFN- , IL-2, and IL-8 between breeds. The lifestyle also affected serum levels of IL-2. The main conclusion of this study is that Ibizan hounds and crossbred dogs have a serological profile of cytokines that seems to indicate certain protections against infection by L. infantum compared to boxer and purebred breeds.application/pdfenopen accessLeishmaniasis in dogs.Leishmaniasis en los perros.Perros - Enfermedades infecciosas.Dogs - Communicable diseases.Artículohttps://doi.org/10.3390/vetsci9060305https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es