Gourbault, OliviaLlobat Bordes, Maria DoloresProducción Científica UCH 2021UCH. Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos2021-07-202021-07-202021-04-23Llobat, L. & Gourbault, O. (2021). Role of MicroRNAs in human osteosarcoma: future perspectives. Biomedicines, vol. 9, i. 5 (23 apr.), art. 463. DOI: https://doi.org/10.3390/biomedicines90504632227-9059 (Electrónico).http://hdl.handle.net/10637/12890Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2227-9059/9/5/463Este artículo pertenece al número especial "MicroRNAs, tRNA fragments, and circular RNAs: pivotal regulators of gene expression and their roles in human diseases".Osteosarcoma (OS) is a rare form of cancer with high death rate but is one of the most frequent forms of bone cancer in children and adolescents. MiRNAs are small endogenous RNAs that regulate gene expression post-transcriptionally. The discovery of miRNAs could allow us to obtain an earlier diagnosis, predict prognosis and chemoresistance, and lead to the discovery of new treatments in different types of tumors, including OS. Despite the fact that there is currently only one clinical trial being carried out on a single miRNA for solid tumors, it is very probable that the number of clinical trials including miRNAs as prognostic and diagnostic biomarkers, as well as potential therapeutic targets, will increase in the near future. This review summarizes the different miRNAs related to OS and their possible therapeutic application.application/pdfesopen accessOsteosarcoma - Treatment.Huesos - Cáncer - Tratamiento.Tumor markers.Bones - Cancer - Treatment.Marcadores tumorales.Osteosarcoma - Tratamiento.Artículohttps://doi.org/10.3390/biomedicines9050463https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es