Micó Ruiz, Juan CarlosAmigó Borrás, SalvadorCaselles Moncho, AntonioRomero Sánchez, Pantaleón DavidProducción Científica UCH 2021UCH. Departamento de Matemáticas, Física y Ciencias Tecnológicas2021-11-042021-11-042021-05-03Mico, J.C., Amigó, S., Caselles, A. & Romero, P.D. (2021). Biology and personality : a mathematical approach to the body-mind problem. Kybernetes, vol. 50, i. 5 (03 may.), pp. 1566-1587. DOI: https://doi.org/10.1108/K-03-2020-01380368-492Xhttp://hdl.handle.net/10637/13121Este artículo se encuentra disponible en la siguiente URL: https://www.emerald.com/insight/content/doi/10.1108/K-03-2020-0138/full/htmlThis is the pre-peer reviewed version of the following article: Mico, J.C., Amigó, S., Caselles, A. and D. Romero, P. (2021). Biology and personality: a mathematical approach to the body-mind problem. Kybernetes, vol. 50, i. 5, pp. 1566-1587, which has been published in final form at https://doi.org/10.1108/K-03-2020-0138Este es el pre-print del siguiente artículo: Mico, J.C., Amigó, S., Caselles, A. and D. Romero, P. (2021). Biology and personality: a mathematical approach to the body-mind problem. Kybernetes, vol. 50, i. 5, pp. 1566-1587, que se ha publicado de forma definitiva en https://doi.org/10.1108/K-03-2020-0138Purpose – The purpose of this paper is to investigate the body-mind problem from a mathematical invariance principle in relation to personality dynamics in the psychological and the biological levels of description. Design/methodology/approach – The relationship between the two mentioned levels of description is provided by two mathematical models: the response model and the bridge model. The response model (an integro-differential equation) is capable to reproduce the personality dynamics as a consequence of a determined stimulus. The invariance principle asserts that the response model can reproduce personality dynamics at the two levels of description. The bridge model (a second order partial differential equation) can be deduced as a consequence of this principle: it provides the co-evolution of the General Factor of Personality (GFP) (mind), the c-fos and DRD3 gens, and the glutamate neurotransmitter (body). Findings – An application case is presented by setting up two experimental designs: a previous pilot AB pseudoexperimental design with one subject and a subsequent ABC experimental design with another subject. The stimulus used is the stimulant drug Methylphenidate (MPD). The response and bridge models are validated with the outcomes of these experiments. Originality/value – The mathematical approach here presented is based on a holistic personality model developed in the last few years: the Unique Trait Personality Theory, which claims for a single personality trait to understand the overall human personality: the GFP.application/pdfenopen accessMente y cuerpo - Modelos matemáticos.Mind and body - Mathematical models.Personality - Mathematicals models.Personalidad - Modelos matemáticos.Psicología - Modelos matemáticos.Psychology - Mathematical models.Artículohttps://doi.org/10.1108/K-03-2020-0138https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es