Ruiz Artacho, PedroLecumberri Villamediana, RamónTrujillo Santos, JavierFont Puig, CarmeLópez Núñez, Juan J.Peris Sifre, María LuisaProducción Científica UCH 2022UCH. Departamento de Medicina y Cirugía2023-05-302023-05-302022-08-26Ruiz-Artacho, P., Lecumberri, R., Trujillo-Santos, J., Font, C., López-Núñez, J. J., Peris, M. L., Díaz Pedroche, C., Lobo, J. L., López Jiménez, L., López Reyes, R., Jara Palomares, L., Pedrajas, J. M., Mahé, I., Monreal, M. & The Riete Investigators (2022). Cancer histology and natural history of patients with lung cancer and venous thromboembolism. Cancers, vol. 14, i. 17 (26 aug.), art. 4127. DOI: https://doi.org/10.3390/cancers141741272072-6694 (Electrónico)http://hdl.handle.net/10637/14365Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2072-6694/14/17/4127Este artículo de investigación pertenece al número especial "Venous Thromboembolism and Cancer".En este artículo de investigación también participan: Carmen Díaz Pedroche, José Luis Lobo, Luciano López Jiménez, Raquel López Reyes, Luis Jara Palomares, José María Pedrajas, Isabelle Mahé, Manuel Monreal and The RIETE Investigators.Background: In patients with lung cancer and venous thromboembolism (VTE), the influence of cancer histology on outcome has not been consistently evaluated. Methods: We used the RIETE registry (Registro Informatizado Enfermedad TromboEmbólica) to compare the clinical characteristics and outcomes during anticoagulation in patients with lung cancer and VTE, according to the histology of lung cancer. Results: As of April 2022, there were 482 patients with lung cancer and VTE: adenocarcinoma 293 (61%), squamous 98 (20%), small-cell 44 (9.1%), other 47 (9.8%). The index VTE was diagnosed later in patients with squamous cancer than in those with adenocarcinoma (median, 5 vs. 2 months). In 50% of patients with adenocarcinoma, the VTE appeared within the first 90 days since cancer diagnosis. During anticoagulation (median 106 days, IQR: 45–214), 14 patients developed VTE recurrences, 15 suffered major bleeding, and 218 died: fatal pulmonary embolism 10, fatal bleeding 2. The rate of VTE recurrences was higher than the rate of major bleeding in patients with adenocarcinoma (11 vs. 6 events), and lower in those with other cancer types (3 vs. 9 events). On multivariable analysis, patients with adenocarcinoma had a non-significantly higher risk for VTE recurrences (hazard ratio [HR]: 3.79; 95%CI: 0.76–18.8), a lower risk of major bleeding (HR: 0.29; 95%CI: 0.09–0.95), and a similar risk of mortality (HR: 1.02; 95%CI: 0.76–1.36) than patients with other types of lung cancer. Conclusions: In patients with lung adenocarcinoma, the rate of VTE recurrences outweighed the rate of major bleeding. In patients with other lung cancers, it was the opposite.application/pdfenopen accessLungs - Cancer.Pulmones - Cáncer.Thrombophlebitis.Pulmones - Histología.Tromboflebitis.Lungs - Histology.Artículohttps://doi.org/10.3390/cancers14174127https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es