Changes in circulating glycerol, free fatty acids and glucose levels following liver transplant in the pig.

Abstract

Female pigs, fasted overnight, received an orthotopic liver transplant. During the unhepatic phase, both blood glycerol and plasma free fatty acid concentrations increased, returning to basal values after the transplant, indicating that the liver is the main receptor of these products released in the blood from the glyceride breakdown in peripheral fat deposits. Blood glucose level rose during the unhepatic phase, probably due in part to the perfusion of glucosated saline received by the animals during this phase. After liver transplant, blood glucose levels progressively decreased and this effect was greatly reduced by administering L-alanine. Our data indicate that metabolic changes in the donor's liver diminish the availability of gluconeogenetic substrates immediately following transplant, while administration of exogenous alanine permits faster restoration of gluconeogenetic function in the transplanted liver.