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Ethanol intake during lactation impairs milk production in rats and affects growth and metabolism of suckling pups.


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Título : Ethanol intake during lactation impairs milk production in rats and affects growth and metabolism of suckling pups.
Autor : Tavares do Carmo, Maria das Graças
Oller do Nascimento, C.M.
Martín, A.
Herrera Castillón, Emilio.
Materias: AlcoholLactationMalnutritionMilk productionPup's growthLiverBrainRat
Resumen : From parturition, lactating Wistar rats were given 20% alcohol in drinking water and fed a solid diet ad lib (group AL). Pair-fed (PF) and control (C) rats were fed solid diet and given water ad lib (C). All animals were sacrificed on the 12th day of lactation. Ethanol treatment decreased food intake and milk production in lactating rats to a greater level than in PF rats, and a greater reduction in body weight of the AL pups was noted. Brain weight, protein concentration, and DNA content were also lower in pups of AL dams than of PF dams, whereas liver glycogen concentration was higher in the former. Pups from AL dams had higher circulating levels of [3-OH-butyrate, triglyceride, and free fatty acids than those from either C or PF dams. Plasma glucose concentration was lower in both PF and AL than in C pups, whereas the AL group had lower plasma protein concentration than any of the other groups. We conclude that maternal alcohol intake during lactation greatly impairs milk production, and although the known increase of lipid content in milk in rats studied under similar conditions allows an enhanced lipidic components in the pups, this adaptation does not allow normal growth and brain development.
Descripción : En: Alcohol, ISSN 0741-8329 1999. n. 18 : 71-76 p.
URI : http://hdl.handle.net/10637/866
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Fecha de publicación : 19-sep-1999
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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