Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/8319
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.creatorSwider, R.-
dc.creatorPascual-Teresa Fernández, Beatriz de-
dc.creatorZapico Rodríguez, José María-
dc.creatorMaslyk, Maciej-
dc.date2015es
dc.date.accessioned2017-02-28T05:00:18Z-
dc.date.available2017-02-28T05:00:18Z-
dc.date.issued2015-02-28-
dc.identifier000000645269es
dc.identifier.urihttp://hdl.handle.net/10637/8319-
dc.descriptionEn: RSC Advances. ESSN. 2046-2069. 2015, 5, 72482es
dc.descriptionFinanciado con cargo a proyectos de I+D nacional con referencias (CTQ2011-24741)es
dc.description.abstractA new series of 4,5,6,7-tetrabromobenzotriazole (TBB) derivatives was synthesized and characterized as CK2 inhibitors. They were readily synthesized using a click chemistry approach based on a Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC). Some of the synthesized compounds present interesting inhibitory activities using an in vitro assay, with Ki values in the low micro molar range and a high degree of selectivity against a panel of 24 kinases. Selected compounds were tested for their antiproliferative effect on several cancer cell lines, and for proapoptotic activity towards human Jurkat T-leukemia and MCF-7 breast adenocarcinoma cells, showing that they can be proposed as promising anticancer agents. Docking studies as well as crystallographic analysis allowed us to identify ligand –CK2 interactions that account for the molecular recognition process, and can help to further optimize this family of compounds as CK2 inhibitors.en_EN
dc.formatapplication/pdfes
dc.language.isoenes
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.eses
dc.subjectProteínases
dc.subjectAnálisis-
dc.titleSynthesis, biological activity and structural study of new benzotriazole-based protein kinase CK2 inhibitors.es
dc.typeArtículoes
dc.description.versionPreprinten
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/8319-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/645269/thumb_europeana/645269.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.