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dc.creatorFilipiak, Kamila-
dc.creatorHidalgo, María-
dc.creatorSilva, Jose Manuel-
dc.creatorFabre, Benjamin-
dc.creatorCarbajo, Rodrigo J.-
dc.creatorPineda-Lucena, Antonio-
dc.creatorRamos González, Ana-
dc.creatorPascual-Teresa Fernández, Beatriz de-
dc.creatorPascual Teresa, Sonia de-
dc.date2013es
dc.date.accessioned2015-09-26T04:00:14Z-
dc.date.available2015-09-26T04:00:14Z-
dc.date.issued2013-09-26-
dc.identifier000000625346es
dc.identifier.urihttp://hdl.handle.net/10637/7722-
dc.descriptionEn: Food & Function. EISSN. 2042-650x. 2013, december, doi: 10.1039/c3fo60465aes
dc.description.abstractGallic acid and anthocyanins are abundant plant food bioactives present in many fruits and vegetables, being especially important in the composition of berries. Gallic acid has been shown to possess cytotoxic properties in several cancer cell lines and to inhibit carcinogenesis in animal models. However, its 10 mechanism of action is not yet fully understood. The aim of this study was to elucidate whether the observed inhibitory activity of gallic acid against gelatinases corresponds to its cytotoxic activity in HT1080 cells and to determine if anthocyanins could have a similar behavior. Gallic acid and delphinidin-3-glucoside have shown selective cytotoxicity towards HT1080 cells. Further analysis in a migration and invasion assay showed anti-invasive activity of gallic acid, delphinidin and pelargonidin-3- 15 glucosides. Zymographic analysis demonstrated the inhibitory activity of gallic acid at the level of secreted and activated gelatinases. Moreover, gallic acid inhibited MMP-2 and MMP-9 proteolytic activity with very similar potency. NMR and molecular modelling experiments confirmed the interaction of gallic acid with MMP-2, and suggested that it takes place within the catalytic center. In this work we give some new experimental data supporting the role of those compounds in the inhibition of 20 metalloproteases as the mechanism for its cytotoxic activity against fibrosarcoma.en_EN
dc.formatapplication/pdfes
dc.language.isoenes
dc.relationFinanciado con cargo a proyectos de I+D nacional con referencias (CTQ2011-24741, SAF2011-28350 and AGL2012-30803).es
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.eses
dc.subjectMetaloproteínases
dc.subjectAnálisis-
dc.titleDietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells: a study on the mode of action.es
dc.typeArtículoes
dc.description.versionPost-print del autores
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/7722-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/625346/thumb_europeana/625346.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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