Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/7665
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.creatorRojo Blanco, Davides
dc.creatorRupérez Pascualena, Francisco Javieres
dc.creatorBarbas Arribas, Coral.es
dc.date2012es
dc.date.accessioned2015-09-16T04:00:13Z-
dc.date.available2015-09-16T04:00:13Z-
dc.date.issued2012-09-16-
dc.identifier000000624718es
dc.identifier.urihttp://hdl.handle.net/10637/7665-
dc.descriptionEn: Bioanalysis. ESSN. 1757-6199. 2012, 4 (10): 1235-1243es
dc.description.abstractThe metabolome is the complete set of small molecules coming from protein activity (anabolism and catabolism) in living systems. They have a broad range of chemical structures and physico-chemical properties and therefore different analytical methodologies are necessary. Highly polar metabolites, such as sugars and most amino acids are not retained by conventional reversed phase liquid (RP-LC) chromatography columns. Without sufficient retention, coelution may result in identification problems while the detection of compounds by mass spectrometry at low concentrations may also be problematic due to ion suppression. In order to retain compounds based on their hydrophilicity, polar stationary phases and hydrophilic interaction liquid chromatography (HILIC) provide a complementary tool to RP-LC for untargeted comprehensive metabolite fingerprinting. However, robustness of the methods is still limiting their applications. This review focuses on sample pre-treatment, stationary phases, analytical methods and applications for polar compound analysis in biological matrices.en-EN
dc.formatapplication/pdfes
dc.language.isoenes
dc.relationFinanciado con cargo a proyectos de I+D nacional con referencia CTQ 2011-23562es
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.eses
dc.subjectMetabolitos.es
dc.subjectPolar metabolitesen-EN
dc.subjectMetabolic fingerprintingen-EN
dc.subjectBiomarkersen-EN
dc.subjectHILICen-EN
dc.titleLC-MS metabolomics of polar compounds.es
dc.typeArtículoes
dc.description.versionPost-print del autores
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/7665-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/624718/thumb_europeana/624718.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.