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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Viana Arribas, Marta | - |
dc.creator | Herrera Castillón, Emilio. | - |
dc.creator | Bonet Serra, Bartolomé | - |
dc.date | 1996 | - |
dc.date.accessioned | 2011-09-19T15:40:20Z | - |
dc.date.available | 2011-09-19T15:40:20Z | - |
dc.date.issued | 1996-09-19T15:40:20Z | - |
dc.identifier | 000000406369 | - |
dc.identifier.uri | http://hdl.handle.net/10637/755 | - |
dc.description | En: Diabetologia. ISSN 0012-186x 1996. n. 39 : 1041-1046 p. | - |
dc.description.abstract | We wanted to determine whether administration of vitamin E could reduce the production of free radicals which could play a role in the teratogenic effects of diabetes mellitus. Diabetes was induced in Wistar rats by the intravenous administration of streptozotocin. The animals were divided into six groups: one with no supplement (D) and two, supplemented during pregnancy either with oral vitamin E (150 mg/day) (D + E) or with a placebo (safflower oil) (D + 0). Three other groups were kept under the same conditions, but were treated with insulin: D + I, D + I + E and D + I + 0. There were three groups of matched controls: C, C + E and C + 0. All animals were killed on day 11.5 of pregnancy. In C animals the percentages of reabsorptions and malformations were 1.3 and 2 %, respectively, comapred with 23.6, 24.3, 6.2 and 13.2 %, respectively in D and D + I groups. The crown-rump length, number of somites, and protein and DNA content were: higher in C animals than in the diabetic rats, independent of insulin treatment. When vitamin E was administered no changes in these parameters were observed in C and D + I animals; however, in the D mothers it reduced the rate of embryo malformations to 4.6 % and increased the crown-rump length and the number of somites. However, vitamin E did not modify the protein and DNA content and the percentage of reabsorptions. In conclusion, administration of vitamin E to diabetic animals decreases the rate of embryo malformations and increases their size and maturation, supporting a role for free radicals in the teratogenic effects of diabetes. | en_EN |
dc.format | application/pdf | - |
dc.language.iso | en | - |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | - |
dc.subject | Diabetes mellitus | en_EN |
dc.subject | Teratogenesis | en_EN |
dc.subject | Free-radicals | en_EN |
dc.subject | Pregnancy | en_EN |
dc.subject | vitamin E | en_EN |
dc.title | Teratogenic effects of diabetes mellitus in the rat : prevention by vitamin E. | - |
dc.type | Artículo | - |
europeana.dataProvider | UNIVERSIDAD SAN PABLO CEU | - |
europeana.isShownAt | http://hdl.handle.net/10637/755 | - |
europeana.object | http://repositorioinstitucional.ceu.es/visor/libros/406369/thumb_europeana/406369.jpg | - |
europeana.provider | Hispana | - |
europeana.rights | http://creativecommons.org/publicdomain/zero/1.0/ | - |
europeana.type | TEXT | - |
dc.centro | Universidad San Pablo-CEU | - |
Aparece en las colecciones: | Facultad de Farmacia |
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