Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/664

Streptozotocin-induced diabetes decreases mammary gland lipoprotein lipase activity and messenger ribonucleic acid in pregnant and nonpregnant rats.

Título : Streptozotocin-induced diabetes decreases mammary gland lipoprotein lipase activity and messenger ribonucleic acid in pregnant and nonpregnant rats.
Autor : Blanco-Dolado, Laura
Herrera Castillón, Emilio.
Martín Hidalgo, Antonia
Materias: Streptozotocin diabetesLipoprotein lipaseMammary glandPregnancymRNARat
Resumen : Diabetes mellitus is associated with a reduction of lipoprotein lipase (LPL) activity in adipose tissue and development of · hypertriglyceridemia. To determine how a condition of severe insulin deficiency affects mammary gland LPL activity and mRNA expression during late pregnancy, streptozotocin (STZ) treated (40 mg/kg) and non-treated (control) virgin and 20 day pregnant rats were studied. In control rats, both LPL activity and mRNA were higher in pregnant than in virgin rats. When compared to control rats, STZ-treated rats, either pregnant or virgin, showed decreased LPL activity and mRNA content. Furthermore, mammary gland LPL activity was linearly correlated with mRNA content, and either variable was linearly correlated with plasma insulin levels. Thus, insulin deficiency impairs the expression of LPL in mammary glands, revealing the role of insulin as a modulator of the enzyme at the mRNA expression level.
Descripción : En: International Journal of experimental diabetes research. 2002. n. 3 : 61-68 p. 1560-4284
URI : http://hdl.handle.net/10637/664
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Fecha de publicación : 19-sep-2002
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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