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Human milk bactericidal properties : effect of lyophilization and relation to maternal factors and milk components


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Título : Human milk bactericidal properties : effect of lyophilization and relation to maternal factors and milk components
Autor : Salcedo, Jaime
Gormaz, María
López Mendoza, María Carmen
Nogarotto, Elisabetta
Silvestre Castelló, Dolores
Materias: Leche maternaMother's milkLactancia maternaBreast feedingLiofilizaciónFreeze-drying
Editorial : John Wiley & Sons
Citación : Salcedo, J., Gormaz, M., López-Mendoza, M.C., Nogarotto, E., & Silvestre, D. (2015). Human milk bactericidal properties : effect of lyophilization and relation to maternal factors and milk components. Journal of Pediatric Gastroenterology and Nutrition, 60(4), 527–532. https://doi.org/10.1097/MPG.0000000000000641
Resumen : Objective: Lyophilization appears to be a viable method for storing human milk, assuring no microbiological contamination and preserving its health benefits and antibacterial properties. The aim of the study is to evaluate and compare the effects of different storage methods (lyophilization and freezing at −20°C and −80°C) and maternal factors (gestational length or time postpartum) upon the microbiological contents and bactericidal activity of human milk. The possible relation between bactericidal activity and the content of certain nutrients and functional components is also investigated. Methods: Microbiological content, bactericidal activity, sialic acid, and ganglioside contents, as well as protein, fat, and lactose concentrations were assessed in 125 human milk samples from 65 healthy donors in the Human Milk Bank of La Fe (Valencia, Spain). Results: Lyophilization and storage at −80°C significantly reduced the content of mesophilic aerobic microorganisms and Staphylococcus epidermidis when compared with storage at −20°C. Bactericidal activity was not significantly modified by lyophilization when compared with freezing at either −20°C or −80°C. Bactericidal activity was not correlated with fat, protein, or lactose content, but was significantly correlated to ganglioside content. The bactericidal activity was significantly greater (P < 0.05) in mature milk and in milk from women with term delivery than in milk from early lactation (days 1–7 postpartum) and milk from women with preterm delivery, respectively. Conclusions: Lyophilization and storage at −80°C of human milk yields similar results and are superior to storage at −20C with regard to microbial and bactericidal capacities, being a feasible alternative for human milk banks.
Descripción : Este recurso no está disponible en acceso abierto por política de la editorial.
URI : http://hdl.handle.net/10637/16285
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN : 0277-2116
1536-4801 (Electrónico)
Fecha de publicación : abr-2015
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos





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