Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/15729

Osteostatin, a peptide for the future treatment of musculoskeletal diseases

Título : Osteostatin, a peptide for the future treatment of musculoskeletal diseases
Autor : Lozano Borregón, Daniel
Rodríguez de Gortázar Alonso-Villalobos, María Arántzazu
Portal Núñez, Sergio
Materias: BoneOsteoporosisFractures.AgingOsteostatin
Editorial : Elsevier
Citación : Daniel Lozano, Arancha R. Gortazar, Sergio Portal-Núñez, Osteostatin, a peptide for the future treatment of musculoskeletal diseases, Biochemical Pharmacology, Volume 223, 2024, 116177, ISSN 0006-2952, https://doi.org/10.1016/j.bcp.2024.116177
Resumen : Nowadays, the treatment of musculoskeletal diseases represents a major challenge in the developed world. Diseases such as osteoporosis, osteoarthritis and arthritis have a high incidence and prevalence as a consequence of population aging, and they are also associated with a socioeconomic burden. Many efforts have been made to find a treatment for these diseases with various levels of success, but new approaches are still needed to deal with these pathologies. In this context, one peptide derived for the C-terminal extreme of the Parathormone related Peptide (PTHrP) called Osteostatin can be useful to treat musculoskeletal diseases. This pentapeptide (TRSAW) has demonstrated both in different in vitro and in vivo models, its role as a molecule with anti-resorptive, anabolic, anti-inflammatory, and anti-antioxidant properties. Our aim with this work is to review the Osteostatin main features, the knowledge of its mechanisms of action as well as its possible use for the treatment of osteoporosis, bone regeneration and fractures and against arthritis given its anti-inflammatory properties.
URI : http://hdl.handle.net/10637/15729
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Open Access
ISSN : 1873-2968
Cubierto por: Acuerdo Transformativo – 2024
Fecha de publicación : 27-mar-2024
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Medicina





Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.