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dc.contributor.otherUniversidad San Pablo-CEU. Facultad de Farmacia. Departamento de Ciencias Farmacéuticas y de la Salud-
dc.contributor.otherGrupo: Productos naturales (CEU-PRONAT)-
dc.creatorLeón-González, Antonio J.-
dc.creatorAcero de Mesa, Nuria-
dc.creatorMuñoz Mingarro, Dolores-
dc.creatorNavarro Zafra, Inmaculada-
dc.creatorMartín-Cordero, Carmen-
dc.date.accessioned2024-03-21T17:57:19Z-
dc.date.available2024-03-21T17:57:19Z-
dc.date.issued2015-
dc.identifier.citationLeón-González AJ, Acero N, Muñoz-Mingarro D, Navarro I, Martín-Cordero C. Chalcones as Promising Lead Compounds on Cancer Therapy. Curr Med Chem. 2015;22(30):3407-25. doi: 10.2174/0929867322666150729114829-
dc.identifier.issn1875-533X-
dc.identifier.urihttp://hdl.handle.net/10637/15666-
dc.descriptionVersión en acceso abierto siguiendo política de la revista-
dc.description.abstractChalcones constitute a group of phenolic compounds that command an increasing interest on cancer research. Natural chalcones are widespread through the plant kingdom. The most abundant and investigated chalcones are isoliquiritigenin, flavokawain and xanthohumol, which are present in the Fabaceae, Piperaceae, Cannabaceae, and Moraceae families. These chalcones have been shown to be promising lead antitumor-chemopreventive drugs by three different activities: antioxidants, cytotoxic and apoptosis inducers. In recent years, SAR (structure-activity relationship) has contributed towards the improvement of anticancer properties of chalcones by substituting aryl rings and introducing heterocyclic moieties. This review summarizes the anticancer activities shown by natural chalcones and the SAR and describes how different chemical moiety modifications could lead them to be therapeutically useful in the treatment of cancer.en_EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.publisherBentham Science Publishers-
dc.relation.ispartofCurrent Medicinal Chemistry-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectApoptosisen_EN
dc.subjectCanceren_EN
dc.subjectChalconeen_EN
dc.subjectChemopreventionen_EN
dc.subjectFlavonoiden_EN
dc.subjectSynthesisen_EN
dc.subjectTubulinen_EN
dc.titleChalcones as Promising Lead Compounds on Cancer Therapyen_EN
dc.typeArtículoes_ES
dc.identifier.doi10.2174/0929867322666150729114829-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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